FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term ERBB2 signaling pathway ID (Ontology) GO:0038128 (Gene Ontology)
Definition The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB2 on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription. ERBB2 receptors are themselves unable to bind to ligands, but act as a signal-amplifying tyrosine kinase within a heterodimeric pair.[ PubMed:16460914 ]
Also Known As "ERBB2 signalling pathway" ; "HER2 signaling pathway" ; "NEU signaling" (for all, see Synonyms field below)
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  cell surface receptor protein tyrosine kinase signaling pathway
   |__ERBB signaling pathway
       |__ERBB2 signaling pathway
           |__ERBB2-EGFR signaling pathway
           |__ERBB2-ERBB3 signaling pathway
           |__ERBB2-ERBB4 signaling pathway
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Is a ERBB signaling pathway
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Synonyms
  • "ERBB2 signalling pathway" EXACT
    "HER2 signaling pathway" EXACT
    "NEU signaling" EXACT
    "receptor tyrosine-protein kinase erbB-2 signaling pathway" EXACT
Secondary IDs
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Reactome:R-HSA-1227986 "Signaling by ERBB2"