FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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Term symbiont-mediated suppression of host JAK-STAT cascade ID (Ontology) GO:0039514 (Gene Ontology)
Definition A process in which a symbiont interferes with, inhibits or disrupt a JAK-STAT signal cascade in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.[ PubMed:20624917 PubMed:22919663 PubMed:27437422 PubMed:29924996 PubMed:31413201 ]
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  symbiont-mediated perturbation of host signal transduction pathway
   |__symbiont-mediated suppression of host signal transduction pathway
       |__symbiont-mediated suppression of host JAK-STAT cascade
           |__symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host IRF9 activity
           |__symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host TYK2 activity
           |__symbiont-mediated suppression of host JAK-STAT cascade via inhibition of JAK1 activity
           |__symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT activity
               |__symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity
               |__symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity
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Is a symbiont-mediated suppression of host signal transduction pathway
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Synonyms
  • "disruption by virus of host JAK-STAT cascade" NARROW
    "down-regulation by virus of host JAK-STAT cascade" NARROW
    "downregulation by virus of host JAK-STAT cascade" NARROW
    "inhibition by virus of host JAK-STAT cascade" NARROW
    "negative regulation by virus of host JAK-STAT cascade" NARROW
    "suppression by virus of host JAK-STAT cascade" NARROW
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