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| Term | MDA-5 signaling pathway | ID (Ontology) | GO:0039530 (Gene Ontology) |
| Definition | The series of molecular signals initiated by the binding of dsRNA from another organism to the cytoplasmic pattern recognition receptor (PRR) MDA-5 (also known as IFIH1). MDA-5 detects RNA synthesized during viral replication or shed by non-viral pathogens, and triggers a signaling pathway to protect the host against infection, for example by inducing the expression of cytokines.[ PubMed:19620789 PubMed:33087405 ] | ||
| Also Known As | "IFIH1 signaling pathway" ; "MDA-5 signalling pathway" ; "melanoma differentiation-associated gene 5 signaling pathway" | ||
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pattern recognition receptor signaling pathway__ intracellular receptor signaling pathway________| cytoplasmic pattern recognition receptor signaling pathway |__MDA-5 signaling pathway |
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| Is a | cytoplasmic pattern recognition receptor signaling pathway | ||
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