General Information
Term	symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host TYK2 activity	ID (Ontology)	GO:0039574 (Gene Ontology)
Definition	A process in which a symbiont interferes with, inhibits or disrupt a JAK-STAT signal cascade in the host organism by reducing the activity of host TYK2 (tyrosine kinase 2). TYK2 is an intracellular signal-transducing tyrosine kinase involved in numerous cytokines and interferons signaling pathways and transmits the cytokine signal by phosphorylating receptor subunits.[ PubMed:16987978 PubMed:19085955 ]
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General Information

Term

symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host TYK2 activity

ID (Ontology)

GO:0039574 (Gene Ontology)

Definition

A process in which a symbiont interferes with, inhibits or disrupt a JAK-STAT signal cascade in the host organism by reducing the activity of host TYK2 (tyrosine kinase 2). TYK2 is an intracellular signal-transducing tyrosine kinase involved in numerous cytokines and interferons signaling pathways and transmits the cytokine signal by phosphorylating receptor subunits.[ PubMed:16987978 PubMed:19085955 ]

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

No relevant statements available

symbiont-mediated suppression of host signal transduction pathway
 |__symbiont-mediated suppression of host JAK-STAT cascade________
symbiont-mediated perturbation of host innate immune response     |
 |__symbiont-mediated suppression of host innate immune response__|
symbiont-mediated suppression of host immune response             |
 |__symbiont-mediated suppression of host innate immune response__|
                                                                  symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host TYK2 activity

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Is a	symbiont-mediated suppression of host JAK-STAT cascade symbiont-mediated suppression of host innate immune response
Part of
Synonyms & Secondary IDs
Synonyms
	"disruption by virus of host JAK-STAT cascade via inhibition of host TYK2 activity" NARROW "suppression by virus of host JAK-STAT cascade via inhibition of host TYK2 activity" NARROW "suppression by virus of host non-receptor tyrosine-protein kinase TYK2 activity" NARROW "suppression by virus of host TYK2 activity" NARROW
Secondary IDs

External Crossreferences & Linkouts
	VZ:720

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Parents/Children
View Depth

Relationships

Is a

symbiont-mediated suppression of host JAK-STAT cascade
symbiont-mediated suppression of host innate immune response

Part of

Synonyms & Secondary IDs

Synonyms

"disruption by virus of host JAK-STAT cascade via inhibition of host TYK2 activity" NARROW
"suppression by virus of host JAK-STAT cascade via inhibition of host TYK2 activity" NARROW
"suppression by virus of host non-receptor tyrosine-protein kinase TYK2 activity" NARROW
"suppression by virus of host TYK2 activity" NARROW

Secondary IDs

External Crossreferences & Linkouts

VZ:720