FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term symbiont-mediated suppression of host ISG15-protein conjugation ID (Ontology) GO:0039579 (Gene Ontology)
Definition Any process in which a symbiont inhibits or disrupts a host ubiquitin-like protein ISG15 conjugation to a substrate. ISG15 is a ubiquitin-like protein that is conjugated to lysine residues on various target proteins. For example, some viruses escape the antiviral activity of ISG15 by using different mechanisms; the influenza B virus NS1 protein blocks the covalent linkage of ISG15 to its target proteins by directly interacting with ISG15, while the papain-like protease from the coronavirus cleaves ISG15 derivatives.[ PubMed:11157743 PubMed:18078692 PubMed:18604270 PubMed:32845033 ]
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symbiont-mediated perturbation of host innate immune response__
symbiont-mediated suppression of host immune response__________|
                                                               symbiont-mediated suppression of host innate immune response
                                                                |__symbiont-mediated suppression of host ISG15-protein conjugation
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Is a symbiont-mediated suppression of host innate immune response
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Synonyms
  • "suppression by virus of host ISG15 activity" RELATED
    "suppression by virus of host ISG15-protein conjugation" NARROW
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