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| Term | symbiont-mediated suppression of host ISG15-protein conjugation | ID (Ontology) | GO:0039579 (Gene Ontology) |
| Definition | Any process in which a symbiont inhibits or disrupts a host ubiquitin-like protein ISG15 conjugation to a substrate. ISG15 is a ubiquitin-like protein that is conjugated to lysine residues on various target proteins. For example, some viruses escape the antiviral activity of ISG15 by using different mechanisms; the influenza B virus NS1 protein blocks the covalent linkage of ISG15 to its target proteins by directly interacting with ISG15, while the papain-like protease from the coronavirus cleaves ISG15 derivatives.[ PubMed:11157743 PubMed:18078692 PubMed:18604270 PubMed:32845033 ] | ||
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symbiont-mediated perturbation of host innate immune response__ symbiont-mediated suppression of host immune response__________| symbiont-mediated suppression of host innate immune response |__symbiont-mediated suppression of host ISG15-protein conjugation |
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| Is a | symbiont-mediated suppression of host innate immune response | ||
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