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General Information
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| Term |
PKR/eIFalpha signaling |
ID (Ontology) |
GO:0039585 (Gene Ontology) |
| Definition |
An intracellular signaling cassette that starts with activation and autophosphorylation of PKR (also known as EIF2AK2), which phosphorylates proteins including the translation initiation factor eIF2 to inhibit translation. PKR is activated by stress signals and during the antiviral response, activated by binding to viral double-stranded RNA (dsRNA) leading to inhibition of protein synthesis during viral infection.[ PubMed:21204021 PubMed:22102852 PubMed:27629041 PubMed:9843495 ] |
| Also Known As |
"EIF2AK2 signal transduction" ; "EIF2AK2/PRK signaling" ; "PKR signal transduction" (for all, see Synonyms field below) |
| Comment |
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Links to External Ontologies
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QuickGO data AmiGO data
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Annotations
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Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
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No relevant records available
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Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
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No relevant statements available
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Relationships
