FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term natural killer cell mediated cytotoxicity ID (Ontology) GO:0042267 (Gene Ontology)
Definition The directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
Also Known As "natural killer cell mediated cell death" ; "natural killer cell mediated cell killing" ; "NK cell mediated cell death" (for all, see Synonyms field below)
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Spanning Tree (Parents/Children)
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cell killing
 |__leukocyte mediated cytotoxicity________
leukocyte mediated immunity                |
 |__leukocyte mediated cytotoxicity________|
lymphocyte mediated immunity               |
 |__natural killer cell mediated immunity__|
innate immune response                     |
 |__natural killer cell mediated immunity__|
                                           natural killer cell mediated cytotoxicity
                                            |__natural killer cell degranulation
                                            |   |__regulation of natural killer cell degranulation(+)
                                            |__natural killer cell mediated cytotoxicity directed against tumor cell target
                                            |   |__regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(+)
                                            |__regulation of natural killer cell mediated cytotoxicity
                                                |__negative regulation of natural killer cell mediated cytotoxicity(+)
                                                |__positive regulation of natural killer cell mediated cytotoxicity(+)
                                                |__regulation of natural killer cell degranulation(+)
                                                |__regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(+)
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Is a leukocyte mediated cytotoxicity
natural killer cell mediated immunity
Part of
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Synonyms
  • "killer activity" RELATED
    "natural killer cell mediated cell death" EXACT
    "natural killer cell mediated cell killing" EXACT
    "natural killer cell mediated cytolysis" RELATED
    "natural killer-cell mediated cytolysis" RELATED
    "NK cell mediated cell death" EXACT
    "NK cell mediated cell killing" EXACT
    "NK cell mediated cytolysis" RELATED
    "NK cell mediated cytotoxicity" EXACT
Secondary IDs
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