FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term MHC class I peptide loading complex ID (Ontology) GO:0042824 (Gene Ontology)
Definition A large, multisubunit complex which consists of the MHC class I-beta 2 microglobulin dimer, the transporter associated with antigen presentation (TAP), tapasin (an MHC-encoded membrane protein), the chaperone calreticulin and the thiol oxidoreductase ERp57. Functions in the assembly of peptides with newly synthesized MHC class I molecules.[ PubMed:10631934 ]
Also Known As "peptide-loading complex"
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endoplasmic reticulum
 |__endoplasmic reticulum protein-containing complex___________
membrane                                                       |
 |__membrane protein complex___________________________________|
organelle membrane                                             |
 |__endoplasmic reticulum membrane_____________________________|
protein-containing complex                                     |
 |__membrane protein complex___________________________________|
 |__endoplasmic reticulum protein-containing complex___________|
nuclear outer membrane-endoplasmic reticulum membrane network  |
 |__endoplasmic reticulum membrane_____________________________|
endoplasmic reticulum subcompartment                           |
 |__endoplasmic reticulum membrane_____________________________|
                                                               MHC class I peptide loading complex
                                                                |__TAP complex
                                                                |__Tapasin-ERp57 complex
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Is a membrane protein complex
endoplasmic reticulum protein-containing complex
Part of endoplasmic reticulum membrane
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Synonyms
  • "peptide-loading complex" EXACT
    "PLC" RELATED
Secondary IDs
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