FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term NADPH oxidase complex ID (Ontology) GO:0043020 (Gene Ontology)
Definition A enzyme complex of which the core is a heterodimer composed of a light (alpha) and heavy (beta) chain, and requires the cytosolic regulatory subunits at least NCF1/p47-phox, NCF2/p67-phox, NCF4/p40-phox and the small GTPase RAC1 or RAC2 for activity. Functions in superoxide generation by the NADPH-dependent reduction of O2.[ PubMed:11483596 PubMed:12440767 ]
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Annotations
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Data Class Field Records
Genes (FBgn)  GO_CELLULAR_COMPONENT       2
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 Genes
 NADPH oxidase complex (all annotations which use CV term, excluding "NOT" statements)       2
     part_of | NADPH oxidase complex       2
Spanning Tree (Parents/Children)
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plasma membrane
 |__plasma membrane protein complex__
membrane protein complex             |
 |__plasma membrane protein complex__|
catalytic complex                    |
 |__oxidoreductase complex___________|
                                     NADPH oxidase complex  2 rec.
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Is a plasma membrane protein complex
oxidoreductase complex
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Synonyms
  • "flavocytochrome b558" NARROW
    "respiratory-burst oxidase" RELATED
Secondary IDs
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