FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term negative regulation of catalytic activity ID (Ontology) GO:0043086 (Gene Ontology)
Definition Any process that stops or reduces the activity of an enzyme.
Also Known As "down regulation of enzyme activity" ; "down-regulation of enzyme activity" ; "down-regulation of metalloenzyme activity" (for all, see Synonyms field below)
Comment
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Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS       1
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 Genes
 negative regulation of catalytic activity (all annotations which use CV term, excluding "NOT" statements)       1
     involved_in | negative regulation of catalytic activity       1
Spanning Tree (Parents/Children)
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regulation of molecular function
 |__negative regulation of molecular function__
 |__regulation of catalytic activity___________|
                                               negative regulation of catalytic activity  2 rec.
                                                |__negative regulation of adenylate cyclase activity
                                                |__negative regulation of endoribonuclease activity
                                                |__negative regulation of glycogen (starch) synthase activity
                                                |__negative regulation of guanylate cyclase activity
                                                |__negative regulation of helicase activity
                                                |__negative regulation of hydrolase activity
                                                |   |__negative regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity
                                                |   |__negative regulation of beta-galactosidase activity
                                                |   |__negative regulation of cyclic-nucleotide phosphodiesterase activity
                                                |   |__negative regulation of GTPase activity
                                                |   |__negative regulation of lipase activity(+)
                                                |   |__negative regulation of peptidase activity(+)
                                                |   |__negative regulation of phosphatase activity(+)
                                                |__negative regulation of kinase activity 1 rec.
                                                |   |__negative regulation of glucokinase activity
                                                |   |__negative regulation of protein kinase activity(+) 1 rec.
                                                |__negative regulation of oxidoreductase activity 1 rec.
                                                |   |__negative regulation of nitric-oxide synthase activity 1 rec.
                                                |__negative regulation of polynucleotide adenylyltransferase activity
                                                |__negative regulation of protein ADP-ribosylation
                                                |__negative regulation of RNA-dependent RNA polymerase activity
                                                |__negative regulation of ubiquitin-protein transferase activity
                                                    |__negative regulation of ubiquitin protein ligase activity
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Is a negative regulation of molecular function
regulation of catalytic activity
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Synonyms
  • "down regulation of enzyme activity" EXACT
    "down regulation of metalloenzyme activity" NARROW
    "down-regulation of enzyme activity" EXACT
    "down-regulation of metalloenzyme activity" EXACT
    "downregulation of enzyme activity" EXACT
    "downregulation of metalloenzyme activity" NARROW
    "inhibition of enzyme activity" NARROW
    "inhibition of metalloenzyme activity" NARROW
    "negative regulation of enzyme activity" EXACT
    "negative regulation of metalloenzyme activity" NARROW
Secondary IDs
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