FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term negative regulation of MAPK cascade ID (Ontology) GO:0043409 (Gene Ontology)
Definition Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade.
Also Known As "down regulation of MAPK cascade" ; "down regulation of MAPKKK cascade" ; "down-regulation of MAPK cascade" (for all, see Synonyms field below)
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Annotations
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Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS       3
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Relevant FlyBase reports
 Genes
 negative regulation of MAPK cascade (all annotations which use CV term, excluding "NOT" statements)       3
     involved_in | negative regulation of MAPK cascade       3
Spanning Tree (Parents/Children)
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MAPK cascade
 |__regulation of MAPK cascade________________________________
negative regulation of signal transduction                    |
 |__negative regulation of intracellular signal transduction__|
regulation of intracellular signal transduction               |
 |__regulation of MAPK cascade________________________________|
 |__negative regulation of intracellular signal transduction__|
                                                              negative regulation of MAPK cascade  53 rec.
                                                               |__negative regulation of ERK1 and ERK2 cascade 23 rec.
                                                               |__negative regulation of ERK5 cascade
                                                               |__negative regulation of JNK cascade 29 rec.
                                                               |   |__negative regulation of JUN kinase activity 1 rec.
                                                               |__negative regulation of MAP kinase activity 1 rec.
                                                               |   |__negative regulation of JUN kinase activity 1 rec.
                                                               |__negative regulation of p38MAPK cascade
                                                               |__negative regulation of pheromone response MAPK cascade
                                                               |__negative regulation of stress-activated MAPK cascade 2 rec.
                                                                   |__negative regulation of cell integrity MAPK cascade
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Is a regulation of MAPK cascade
negative regulation of intracellular signal transduction
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Synonyms
  • "down regulation of MAPK cascade" EXACT
    "down regulation of MAPKKK cascade" EXACT
    "down-regulation of MAPK cascade" EXACT
    "down-regulation of MAPKKK cascade" EXACT
    "downregulation of MAPK cascade" EXACT
    "downregulation of MAPKKK cascade" EXACT
    "inhibition of MAPK cascade" NARROW
    "inhibition of MAPKKK cascade" NARROW
    "negative regulation of MAP kinase cascade" EXACT
    "negative regulation of MAP kinase kinase kinase cascade" EXACT
    "negative regulation of MAPKKK cascade" EXACT
    "negative regulation of mitogen activated protein kinase cascade" EXACT
    "negative regulation of mitogen activated protein kinase kinase kinase cascade" EXACT
    "negative regulation of mitogen-activated protein kinase cascade" EXACT
    "negative regulation of mitogen-activated protein kinase kinase kinase cascade" EXACT
Secondary IDs
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