FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term phosphatidylinositol 3-kinase/protein kinase B signal transduction ID (Ontology) GO:0043491 (Gene Ontology)
Definition An intracellular signaling cassette that starts with phosphatidylinositol 3-kinase (PI3K) activation, production of phosphatidylinositol 3-phosphate (PI3P), activation of PDK1, which recruits and ending with the activation of protein kinase B (PKB, also known as Akt). PI3K is activated by cell surface receptors. Note that PTEN is an inhibitor of the pathway.[ PubMed:20517722 PubMed:22952397 ]
Also Known As "phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction" ; "PI3K-PKB/Akt pathway" ; "PI3K/Akt signal transduction" (for all, see Synonyms field below)
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS       6
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 Full annotation statements 
Relevant FlyBase reports
 Genes
 phosphatidylinositol 3-kinase/protein kinase B signal transduction (all annotations which use CV term, excluding "NOT" statements)       6
     involved_in | phosphatidylinositol 3-kinase/protein kinase B signal transduction       6
Spanning Tree (Parents/Children)
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  intracellular signal transduction
   |__intracellular signaling cassette
       |__phosphatidylinositol 3-kinase/protein kinase B signal transduction  33 rec.
           |__regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 28 rec.
               |__negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 11 rec.
               |__positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 17 rec.
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Is a intracellular signaling cassette
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Synonyms
  • "AKT signal transduction" RELATED
    "AKT signaling" RELATED
    "AKT signaling cascade" RELATED
    "AKT signalling cascade" RELATED
    "phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction" EXACT
    "PI3K-PKB/Akt pathway" EXACT
    "PI3K/Akt signal transduction" EXACT
    "PI3K/PKB signal transduction" EXACT
    "PKB signal transduction" RELATED
    "PKB signaling" RELATED
    "PKB signaling cascade" RELATED
    "PKB signalling cascade" RELATED
    "protein kinase B signal transduction" RELATED
    "protein kinase B signaling" RELATED
    "protein kinase B signaling cascade" RELATED
    "protein kinase B signalling cascade" RELATED
Secondary IDs
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Reactome:R-HSA-198203 "PI3K/AKT activation"
Reactome:R-HSA-198323 "AKT phosphorylates targets in the cytosol"
Reactome:R-HSA-198693 "AKT phosphorylates targets in the nucleus"