FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term nuclear pore linkers ID (Ontology) GO:0044612 (Gene Ontology)
Definition A substructure of the nuclear pore complex (NPC) that serves to connect members of the central transport channel (composed of FG-nucleoporins) to the core scaffold (composed of the inner and outer NPC rings). In S. cerevisiae, the linkers are Nic96p and Nup82p. In vertebrates, they are Nup93 and Nup88. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. Both linkers can be isolated in association with specific FG-nucleoporins, complexes that are sometimes referred to as the Nic96 complex (Nic96p-Nsp1p-Nup49p-Nup57p) and the Nup82 complex (Nup82p-Nup116p-Nup159p-Gle2p).[ PubMed:18046406 PubMed:19524430 PubMed:20947011 PubMed:22419078 ]
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nucleus
 |__nuclear protein-containing complex__
nuclear envelope                        |
 |__nuclear pore________________________|
protein-containing complex              |
 |__nuclear protein-containing complex__|
nuclear protein-containing complex      |
 |__nuclear pore________________________|
                                        nuclear pore linkers
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Is a nuclear protein-containing complex
Part of nuclear pore
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Synonyms
  • "Nic96 complex" RELATED
    "Nup82 complex" RELATED
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