FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term protein targeting to ER ID (Ontology) GO:0045047 (Gene Ontology)
Definition The process of directing proteins towards the endoplasmic reticulum (ER) using signals contained within the protein. One common mechanism uses a 16- to 30-residue signal sequence, typically located at the N-terminus of the protein and containing positively charged amino acids followed by a continuous stretch of hydrophobic residues, which directs the ribosome to the ER membrane and initiates transport of the growing polypeptide across the ER membrane.[ ISBN:0716731363 ]
Also Known As "protein targeting to endoplasmic reticulum" ; "protein-endoplasmic reticulum targeting" ; "protein-ER targeting"
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Annotations
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Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS       8
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Relevant FlyBase reports
 Gene Groups Genes
 protein targeting to ER (all annotations which use CV term, excluding "NOT" statements)       3      8
     involved_in | protein targeting to ER       --       8
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establishment of protein localization
 |__protein targeting_______________________________________________
establishment of protein localization to organelle                  |
 |__establishment of protein localization to endoplasmic reticulum__|
                                                                    protein targeting to ER  37 rec.
                                                                     |__post-translational protein targeting to endoplasmic reticulum membrane 9 rec.
                                                                     |   |__post-translational protein targeting to membrane, docking
                                                                     |   |__post-translational protein targeting to membrane, translocation(+) 6 rec.
                                                                     |__SRP-dependent cotranslational protein targeting to membrane 24 rec.
                                                                         |__SRP-dependent cotranslational protein targeting to membrane, docking 1 rec.
                                                                         |__SRP-dependent cotranslational protein targeting to membrane, signal sequence processing
                                                                         |__SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition 3 rec.
                                                                         |__SRP-dependent cotranslational protein targeting to membrane, translocation 12 rec.
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Is a protein targeting
establishment of protein localization to endoplasmic reticulum
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Synonyms
  • "protein targeting to endoplasmic reticulum" EXACT
    "protein-endoplasmic reticulum targeting" EXACT
    "protein-ER targeting" EXACT
Secondary IDs
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