FB2025_05 , released December 11, 2025

General Information
Term	isotype switching	ID (Ontology)	GO:0045190 (Gene Ontology)
Definition	The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus.[ ISBN:0781735149 ]
Also Known As	"class switch recombination" ; "class switching" ; "isotype switch recombination"
Comment
Links to External Ontologies
	QuickGO data AmiGO data
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Records annotated with this term OR any of its CHILD TERMS
No relevant records available
Records annotated with this exact term (annotations to child terms are NOT included)
No relevant records available
Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
No relevant statements available

General Information

Term

isotype switching

ID (Ontology)

GO:0045190 (Gene Ontology)

Definition

The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus.[ ISBN:0781735149 ]

Also Known As

"class switch recombination" ; "class switching" ; "isotype switch recombination"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

No relevant statements available

somatic diversification of immunoglobulins involved in immune response |__somatic recombination of immunoglobulin genes involved in immune response__ lymphocyte activation involved in immune response | |__B cell activation involved in immune response______________________________| somatic recombination of immunoglobulin gene segments | |__somatic recombination of immunoglobulin genes involved in immune response__| B cell activation | |__B cell activation involved in immune response______________________________| isotype switching |__isotype switching to IgA isotypes | |__regulation of isotype switching to IgA isotypes(+) |__isotype switching to IgD isotypes | |__regulation of isotype switching to IgD isotypes(+) |__isotype switching to IgE isotypes | |__interleukin-4-dependent isotype switching to IgE isotypes(+) | |__regulation of isotype switching to IgE isotypes(+) |__isotype switching to IgG isotypes | |__regulation of isotype switching to IgG isotypes(+) |__regulation of isotype switching |__negative regulation of isotype switching(+) |__positive regulation of isotype switching(+) |__regulation of isotype switching to IgA isotypes(+) |__regulation of isotype switching to IgD isotypes(+) |__regulation of isotype switching to IgE isotypes(+) |__regulation of isotype switching to IgG isotypes(+)

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Is a	somatic recombination of immunoglobulin genes involved in immune response B cell activation involved in immune response
Part of
Synonyms & Secondary IDs
Synonyms
	"class switch recombination" EXACT "class switching" EXACT "isotype switch recombination" EXACT
Secondary IDs

External Crossreferences & Linkouts
	Wikipedia:Immunoglobulin_class_switching

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Parents/Children
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Relationships

Is a

somatic recombination of immunoglobulin genes involved in immune response
B cell activation involved in immune response

Part of

Synonyms & Secondary IDs

Synonyms

"class switch recombination" EXACT
"class switching" EXACT
"isotype switch recombination" EXACT

Secondary IDs

External Crossreferences & Linkouts

Wikipedia:Immunoglobulin_class_switching