FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term negative regulation of G protein-coupled receptor signaling pathway ID (Ontology) GO:0045744 (Gene Ontology)
Definition Any process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway.
Also Known As "down regulation of G-protein coupled receptor protein signaling pathway" ; "down-regulation of G-protein coupled receptor protein signaling pathway" ; "downregulation of G-protein coupled receptor protein signaling pathway" (for all, see Synonyms field below)
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS       1
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Genes
 negative regulation of G protein-coupled receptor signaling pathway (all annotations which use CV term, excluding "NOT" statements)       1
     involved_in | negative regulation of G protein-coupled receptor signaling pathway       1
Spanning Tree (Parents/Children)
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G protein-coupled receptor signaling pathway
 |__regulation of G protein-coupled receptor signaling pathway__
regulation of signal transduction                               |
 |__regulation of G protein-coupled receptor signaling pathway__|
 |__negative regulation of signal transduction__________________|
negative regulation of cell communication                       |
 |__negative regulation of signal transduction__________________|
negative regulation of signaling                                |
 |__negative regulation of signal transduction__________________|
negative regulation of response to stimulus                     |
 |__negative regulation of signal transduction__________________|
                                                                negative regulation of G protein-coupled receptor signaling pathway  20 rec.
                                                                 |__desensitization of G protein-coupled receptor signaling pathway 4 rec.
                                                                 |   |__G protein-coupled receptor internalization(+) 4 rec.
                                                                 |   |__inhibitory G protein-coupled receptor phosphorylation(+)
                                                                 |__G protein-coupled receptor catabolic process
                                                                 |__negative regulation of adenosine receptor signaling pathway
                                                                 |__negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway 2 rec.
                                                                 |   |__negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway(+)
                                                                 |   |__negative regulation of adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway
                                                                 |__negative regulation of angiotensin-activated signaling pathway
                                                                 |__negative regulation of chemokine-mediated signaling pathway
                                                                 |   |__negative regulation of C-C chemokine receptor CCR7 signaling pathway
                                                                 |__negative regulation of dopamine receptor signaling pathway
                                                                 |   |__negative regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway
                                                                 |   |__negative regulation of phospholipase C-activating dopamine receptor signaling pathway
                                                                 |__negative regulation of octopamine or tyramine signaling pathway
                                                                 |   |__negative regulation of octopamine signaling pathway(+)
                                                                 |   |__negative regulation of tyramine signaling pathway
                                                                 |__negative regulation of opioid receptor signaling pathway
                                                                 |   |__negative regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway
                                                                 |__negative regulation of opsin-mediated signaling pathway 15 rec.
                                                                 |   |__negative regulation of phospholipase C-activating phototransduction signaling pathway 5 rec.
                                                                 |__negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway 5 rec.
                                                                 |   |__negative regulation of phospholipase C-activating dopamine receptor signaling pathway
                                                                 |   |__negative regulation of phospholipase C-activating phototransduction signaling pathway 5 rec.
                                                                 |__negative regulation of thrombin-activated receptor signaling pathway
                                                                 |__termination of G protein-coupled receptor signaling pathway
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Is a regulation of G protein-coupled receptor signaling pathway
negative regulation of signal transduction
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Synonyms
  • "down regulation of G-protein coupled receptor protein signaling pathway" EXACT
    "down-regulation of G-protein coupled receptor protein signaling pathway" EXACT
    "downregulation of G-protein coupled receptor protein signaling pathway" EXACT
    "inhibition of G-protein coupled receptor protein signaling pathway" NARROW
    "negative regulation of G protein coupled receptor protein signaling pathway" EXACT
    "negative regulation of G protein coupled receptor protein signalling pathway" EXACT
    "negative regulation of G-protein coupled receptor protein signaling pathway" EXACT
    "negative regulation of G-protein coupled receptor protein signalling pathway" EXACT
    "negative regulation of G-protein-coupled receptor protein signalling pathway" EXACT
    "negative regulation of GPCR protein signaling pathway" EXACT
    "negative regulation of GPCR protein signalling pathway" EXACT
Secondary IDs
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