FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term negative regulation of gene expression, epigenetic ID (Ontology) GO:0045814 (Gene Ontology)
Definition An epigenetic process that silences gene expression at specific genomic regions through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or the cytosine DNA methylation.[ PubMed:22243696 ]
Also Known As "down regulation of gene expression, epigenetic" ; "down-regulation of gene expression, epigenetic" ; "downregulation of gene expression, epigenetic"
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Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS       6
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 Genes
 negative regulation of gene expression, epigenetic (all annotations which use CV term, excluding "NOT" statements)       6
     involved_in | negative regulation of gene expression, epigenetic       6
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chromatin remodeling
 |__epigenetic regulation of gene expression_______________
regulation of gene expression                              |
 |__negative regulation of gene expression_________________|
 |__epigenetic regulation of gene expression_______________|
negative regulation of macromolecule biosynthetic process  |
 |__negative regulation of gene expression_________________|
                                                           negative regulation of gene expression, epigenetic  217 rec.
                                                            |__heterochromatin formation 213 rec.
                                                            |   |__constitutive heterochromatin formation(+) 41 rec.
                                                            |   |__dosage compensation by inactivation of X chromosome(+)
                                                            |   |__facultative heterochromatin formation(+) 8 rec.
                                                            |   |__heterochromatin boundary formation 11 rec.
                                                            |   |__pericentric heterochromatin organization
                                                            |   |__regulation of heterochromatin formation(+) 22 rec.
                                                            |   |__regulatory ncRNA-mediated heterochromatin formation(+) 31 rec.
                                                            |__negative regulation of gene expression via chromosomal CpG island methylation
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Is a negative regulation of gene expression
epigenetic regulation of gene expression
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Synonyms
  • "down regulation of gene expression, epigenetic" EXACT
    "down-regulation of gene expression, epigenetic" EXACT
    "downregulation of gene expression, epigenetic" EXACT
    "gene silencing" RELATED
    "inhibition of gene expression, epigenetic" NARROW
Secondary IDs
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Reactome:R-HSA-212300 "PRC2 methylates histones and DNA"
Reactome:R-HSA-5250941 "Negative epigenetic regulation of rRNA expression"