FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term negative regulation of innate immune response ID (Ontology) GO:0045824 (Gene Ontology)
Definition Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response.
Also Known As "down regulation of innate immune response" ; "down-regulation of innate immune response" ; "downregulation of innate immune response"
Comment
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS      32
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Genes
 negative regulation of innate immune response (all annotations which use CV term, excluding "NOT" statements)      32
     acts_upstream_of | negative regulation of innate immune response       3
     involved_in | negative regulation of innate immune response      29
Spanning Tree (Parents/Children)
Only view relationship: 
negative regulation of immune system process
 |__negative regulation of immune response________________
regulation of response to biotic stimulus                 |
 |__negative regulation of response to biotic stimulus____|
 |__regulation of innate immune response__________________|
regulation of defense response                            |
 |__negative regulation of defense response_______________|
 |__regulation of innate immune response__________________|
regulation of response to external stimulus               |
 |__negative regulation of response to external stimulus__|
 |__regulation of innate immune response__________________|
negative regulation of response to stimulus               |
 |__negative regulation of response to biotic stimulus____|
 |__negative regulation of defense response_______________|
 |__negative regulation of response to external stimulus__|
 |__negative regulation of immune response________________|
regulation of immune response                             |
 |__regulation of innate immune response__________________|
 |__negative regulation of immune response________________|
                                                          negative regulation of innate immune response  39 rec.
                                                           |__negative regulation of age-related resistance
                                                           |__negative regulation of antifungal innate immune response 2 rec.
                                                           |__negative regulation of complement activation, alternative pathway
                                                           |__negative regulation of complement activation, lectin pathway
                                                           |__negative regulation of innate immunity memory response
                                                           |__negative regulation of melanization defense response 5 rec.
                                                           |   |__negative regulation melanotic encapsulation of foreign target 3 rec.
                                                           |__negative regulation of natural killer cell mediated immunity
                                                           |   |__negative regulation of natural killer cell cytokine production
                                                           |   |__negative regulation of natural killer cell mediated cytotoxicity(+)
                                                           |   |__negative regulation of natural killer cell mediated immune response to tumor cell(+)
                                                           |__negative regulation of plant-type hypersensitive response
                                                           |__negative regulation of respiratory burst involved in inflammatory response
                                                           |__negative regulation of response to type II interferon
                                                           |   |__negative regulation of type II interferon-mediated signaling pathway
                                                           |__negative regulation of type I interferon-mediated signaling pathway
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Is a negative regulation of response to biotic stimulus
negative regulation of defense response
negative regulation of response to external stimulus
regulation of innate immune response
negative regulation of immune response
Part of
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Synonyms
  • "down regulation of innate immune response" EXACT
    "down-regulation of innate immune response" EXACT
    "downregulation of innate immune response" EXACT
    "inhibition of innate immune response" NARROW
Secondary IDs
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