FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term negative regulation of proteolysis ID (Ontology) GO:0045861 (Gene Ontology)
Definition Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.
Also Known As "down regulation of proteolysis" ; "down-regulation of proteolysis" ; "downregulation of proteolysis" (for all, see Synonyms field below)
Comment
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS      21
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 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 negative regulation of proteolysis (all annotations which use CV term, excluding "NOT" statements)       1     21
     involved_in | negative regulation of proteolysis       --      21
Spanning Tree (Parents/Children)
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proteolysis
 |__regulation of proteolysis___________________________
negative regulation of macromolecule metabolic process  |
 |__negative regulation of protein metabolic process____|
regulation of protein metabolic process                 |
 |__regulation of proteolysis___________________________|
 |__negative regulation of protein metabolic process____|
                                                        negative regulation of proteolysis  44 rec.
                                                         |__negative regulation of membrane protein ectodomain proteolysis 1 rec.
                                                         |__negative regulation of peptidase activity
                                                         |   |__negative regulation of endopeptidase activity(+)
                                                         |   |__negative regulation of metallopeptidase activity
                                                         |   |__negative regulation of serine-type peptidase activity(+)
                                                         |__negative regulation of protein processing 1 rec.
                                                         |   |__negative regulation of peptide hormone processing 1 rec.
                                                         |   |__negative regulation of plasminogen activation
                                                         |   |__negative regulation of protein processing in phagocytic vesicle
                                                         |   |__negative regulation of protein processing involved in protein targeting to mitochondrion
                                                         |   |__zymogen inhibition
                                                         |__negative regulation of proteolysis involved in protein catabolic process 20 rec.
                                                             |__negative regulation of proteasomal protein catabolic process(+) 15 rec.
                                                             |__negative regulation of proteolysis associated with antigen processing and presentation
                                                             |__negative regulation of ubiquitin-dependent protein catabolic process(+) 16 rec.
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Is a regulation of proteolysis
negative regulation of protein metabolic process
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Synonyms
  • "down regulation of proteolysis" EXACT
    "down-regulation of proteolysis" EXACT
    "downregulation of proteolysis" EXACT
    "inhibition of proteolysis" NARROW
    "negative regulation of peptidolysis" EXACT
Secondary IDs
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