FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term negative regulation of smoothened signaling pathway ID (Ontology) GO:0045879 (Gene Ontology)
Definition Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling.
Also Known As "down regulation of smoothened signaling pathway" ; "down-regulation of smoothened signaling pathway" ; "downregulation of smoothened signaling pathway" (for all, see Synonyms field below)
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Annotations
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Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS      59
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 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 negative regulation of smoothened signaling pathway (all annotations which use CV term, excluding "NOT" statements)       1     59
     involved_in | negative regulation of smoothened signaling pathway       --      59
Spanning Tree (Parents/Children)
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smoothened signaling pathway
 |__regulation of smoothened signaling pathway__
regulation of signal transduction               |
 |__regulation of smoothened signaling pathway__|
 |__negative regulation of signal transduction__|
negative regulation of cell communication       |
 |__negative regulation of signal transduction__|
negative regulation of signaling                |
 |__negative regulation of signal transduction__|
negative regulation of response to stimulus     |
 |__negative regulation of signal transduction__|
                                                negative regulation of smoothened signaling pathway  60 rec.
                                                 |__negative regulation of hh target transcription factor activity
                                                 |__negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
                                                 |__negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning
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Is a regulation of smoothened signaling pathway
negative regulation of signal transduction
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Synonyms
  • "down regulation of smoothened signaling pathway" EXACT
    "down-regulation of smoothened signaling pathway" EXACT
    "downregulation of smoothened signaling pathway" EXACT
    "inhibition of smoothened signaling pathway" NARROW
    "negative regulation of hedgehog signaling pathway" EXACT
    "negative regulation of hh signaling pathway" EXACT
    "negative regulation of smoothened activity" RELATED
    "negative regulation of smoothened by patched" NARROW
    "negative regulation of smoothened receptor activity by patched" RELATED
    "negative regulation of smoothened signalling pathway" EXACT
Secondary IDs
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