FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term positive regulation of smoothened signaling pathway ID (Ontology) GO:0045880 (Gene Ontology)
Definition Any process that activates or increases the frequency, rate or extent of smoothened signaling.
Also Known As "positive regulation of hedgehog signaling pathway" ; "positive regulation of hh signaling pathway" ; "positive regulation of smoothened signalling pathway" (for all, see Synonyms field below)
Comment
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS      45
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 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 positive regulation of smoothened signaling pathway (all annotations which use CV term, excluding "NOT" statements)       1     45
     involved_in | positive regulation of smoothened signaling pathway       --      45
Spanning Tree (Parents/Children)
Only view relationship: 
regulation of signal transduction
 |__regulation of smoothened signaling pathway__
 |__positive regulation of signal transduction__|
positive regulation of cell communication       |
 |__positive regulation of signal transduction__|
positive regulation of signaling                |
 |__positive regulation of signal transduction__|
positive regulation of response to stimulus     |
 |__positive regulation of signal transduction__|
                                                positive regulation of smoothened signaling pathway  46 rec.
                                                 |__positive regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
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Is a regulation of smoothened signaling pathway
positive regulation of signal transduction
Part of
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Synonyms
  • "activation of smoothened signaling pathway" NARROW
    "positive regulation of hedgehog signaling pathway" EXACT
    "positive regulation of hh signaling pathway" EXACT
    "positive regulation of smoothened by patched" RELATED
    "positive regulation of smoothened receptor activity by patched" RELATED
    "positive regulation of smoothened signalling pathway" EXACT
    "stimulation of smoothened signaling pathway" NARROW
    "up regulation of smoothened signaling pathway" EXACT
    "up-regulation of smoothened signaling pathway" EXACT
    "upregulation of smoothened signaling pathway" EXACT
Secondary IDs
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