FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
Help Close All Open All
General Information
Term negative regulation of insulin receptor signaling pathway ID (Ontology) GO:0046627 (Gene Ontology)
Definition Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling.
Also Known As "down regulation of insulin receptor signaling pathway" ; "down-regulation of insulin receptor signaling pathway" ; "downregulation of insulin receptor signaling pathway" (for all, see Synonyms field below)
Comment
Links to External Ontologies
  QuickGO data     AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS
    Results list data from multiple species. Click on a button above and use the 'Filter by species' options on the resulting HitList to retrieve species-specific data.
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS      31
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 negative regulation of insulin receptor signaling pathway (all annotations which use CV term, excluding "NOT" statements)       1     31
     acts_upstream_of | negative regulation of insulin receptor signaling pathway       --       1
     involved_in | negative regulation of insulin receptor signaling pathway       --      30
Spanning Tree (Parents/Children)
Only view relationship: 
regulation of signal transduction
 |__negative regulation of signal transduction____________________
 |__regulation of insulin receptor signaling pathway______________|
negative regulation of cell communication                         |
 |__negative regulation of signal transduction____________________|
negative regulation of signaling                                  |
 |__negative regulation of signal transduction____________________|
negative regulation of cellular process                           |
 |__negative regulation of cellular response to insulin stimulus__|
negative regulation of response to stimulus                       |
 |__negative regulation of signal transduction____________________|
 |__negative regulation of cellular response to insulin stimulus__|
regulation of cellular response to insulin stimulus               |
 |__negative regulation of cellular response to insulin stimulus__|
                                                                  negative regulation of insulin receptor signaling pathway  32 rec.
                                                                   |__negative regulation of insulin receptor signaling pathway by insulin receptor internalization
Spanning Tree View Settings
Parents/Children
View Depth
Show hierarchy levels: for parents, for children
hide Relationships
Is a negative regulation of signal transduction
regulation of insulin receptor signaling pathway
negative regulation of cellular response to insulin stimulus
Part of
hide Synonyms & Secondary IDs
Synonyms
  • "down regulation of insulin receptor signaling pathway" EXACT
    "down-regulation of insulin receptor signaling pathway" EXACT
    "downregulation of insulin receptor signaling pathway" EXACT
    "inhibition of insulin receptor signaling pathway" NARROW
    "negative regulation of insulin receptor signalling pathway" EXACT
Secondary IDs
hide External Crossreferences & Linkouts