FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term isotype switching to IgE isotypes ID (Ontology) GO:0048289 (Gene Ontology)
Definition The switching of activated B cells from IgM biosynthesis to IgE biosynthesis, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and IgE constant region gene segments in the immunoglobulin heavy chain locus.[ ISBN:0781735149 PubMed:12370374 PubMed:2113175 PubMed:9186655 ]
Also Known As "class switch recombination to IgE isotypes" ; "class switching to IgE isotypes" ; "isotype switch recombination to IgE isotypes"
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somatic recombination of immunoglobulin genes involved in immune response__
B cell activation involved in immune response______________________________|
                                                                           isotype switching
                                                                            |__isotype switching to IgE isotypes
                                                                                |__interleukin-4-dependent isotype switching to IgE isotypes
                                                                                |   |__regulation of interleukin-4-dependent isotype switching to IgE isotypes(+)
                                                                                |__regulation of isotype switching to IgE isotypes
                                                                                    |__negative regulation of isotype switching to IgE isotypes
                                                                                    |__positive regulation of isotype switching to IgE isotypes(+)
                                                                                    |__regulation of interleukin-4-dependent isotype switching to IgE isotypes(+)
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Synonyms
  • "class switch recombination to IgE isotypes" EXACT
    "class switching to IgE isotypes" EXACT
    "isotype switch recombination to IgE isotypes" EXACT
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