FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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Term negative regulation of cellular process ID (Ontology) GO:0048523 (Gene Ontology)
Definition Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
Also Known As "down regulation of cellular process" ; "down-regulation of cellular process" ; "downregulation of cellular process" (for all, see Synonyms field below)
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regulation of biological process
 |__negative regulation of biological process__
 |__regulation of cellular process_____________|
                                               negative regulation of cellular process  1713 rec.
                                                |__negative regulation of actin filament severing
                                                |__negative regulation of aggregation involved in sorocarp development
                                                |__negative regulation of binding of sperm to zona pellucida
                                                |__negative regulation of cardiac muscle cell contraction
                                                |   |__negative regulation of atrial cardiac muscle cell action potential
                                                |   |__negative regulation of ventricular cardiac muscle cell action potential
                                                |__negative regulation of cartilage condensation
                                                |__negative regulation of cell activation
                                                |   |__negative regulation of astrocyte activation
                                                |   |__negative regulation of endothelial cell activation
                                                |   |__negative regulation of hepatic stellate cell activation
                                                |   |__negative regulation of leukocyte activation(+)
                                                |   |__negative regulation of platelet activation(+)
                                                |   |__negative regulation of skeletal muscle satellite cell activation involved in skeletal muscle regeneration
                                                |__negative regulation of cell adhesion 17 rec.
                                                |   |__negative regulation of cell adhesion in ventricular zone
                                                |   |__negative regulation of cell adhesion involved in sprouting angiogenesis
                                                |   |__negative regulation of cell adhesion involved in substrate-bound cell migration
                                                |   |__negative regulation of cell adhesion mediated by integrin(+)
                                                |   |__negative regulation of cell-cell adhesion(+) 14 rec.
                                                |   |__negative regulation of cell-substrate adhesion(+)
                                                |__negative regulation of cell adhesion molecule production
                                                |__negative regulation of cell communication 483 rec.
                                                |   |__negative regulation of BMP secretion
                                                |   |__negative regulation of c-di-GMP signaling
                                                |   |__negative regulation of cell communication by chemical coupling
                                                |   |__negative regulation of cell communication by electrical coupling(+)
                                                |   |__negative regulation of hormone secretion(+) 7 rec.
                                                |   |__negative regulation of retrograde trans-synaptic signaling by neuropeptide
                                                |   |__negative regulation of signal transduction(+) 459 rec.
                                                |   |__negative regulation of synaptic transmission(+) 19 rec.
                                                |   |__negative regulation of transmission of nerve impulse(+) 3 rec.
                                                |   |__negative regulation of trichome patterning
                                                |   |__negative regulation of Wnt protein secretion 1 rec.
                                                |__negative regulation of cell cycle 97 rec.
                                                |   |__negative regulation of cell cycle process(+) 90 rec.
                                                |   |__negative regulation of cyclin-dependent protein serine/threonine kinase activity
                                                |   |__negative regulation of meiotic cell cycle(+) 7 rec.
                                                |   |__negative regulation of mitotic cell cycle(+) 69 rec.
                                                |__negative regulation of cell differentiation 97 rec.
                                                |   |__maintenance of animal organ identity(+)
                                                |   |__maintenance of imaginal histoblast diploidy 1 rec.
                                                |   |__maintenance of plant organ identity(+)
                                                |   |__negative regulation of antipodal cell differentiation
                                                |   |__negative regulation of cardiac endothelial to mesenchymal transition
                                                |   |__negative regulation of cardiocyte differentiation(+) 5 rec.
                                                |   |__negative regulation of cell development(+) 45 rec.
                                                |   |__negative regulation of cell differentiation involved in embryonic placenta development
                                                |   |__negative regulation of cell differentiation involved in phenotypic switching(+)
                                                |   |__negative regulation of cell differentiation involved in stem cell population maintenance
                                                |   |__negative regulation of cell fate commitment(+) 21 rec.
                                                |   |__negative regulation of chondrocyte differentiation(+)
                                                |   |__negative regulation of embryo sac central cell differentiation
                                                |   |__negative regulation of embryo sac egg cell differentiation
                                                |   |__negative regulation of endodermal cell differentiation(+)
                                                |   |__negative regulation of epithelial cell differentiation(+)
                                                |   |__negative regulation of epithelial to mesenchymal transition(+)
                                                |   |__negative regulation of fat cell differentiation(+)
                                                |   |__negative regulation of hematopoietic progenitor cell differentiation(+) 1 rec.
                                                |   |__negative regulation of hemocyte differentiation(+) 19 rec.
                                                |   |__negative regulation of macrophage derived foam cell differentiation
                                                |   |__negative regulation of mesodermal cell differentiation(+)
                                                |   |__negative regulation of metanephric DCT cell differentiation
                                                |   |__negative regulation of muscle cell differentiation(+) 2 rec.
                                                |   |__negative regulation of myeloid cell differentiation(+)
                                                |   |__negative regulation of myoblast differentiation(+)
                                                |   |__negative regulation of myofibroblast differentiation
                                                |   |__negative regulation of neuron differentiation(+) 15 rec.
                                                |   |__negative regulation of osteoblast differentiation
                                                |   |__negative regulation of pigment cell differentiation(+) 1 rec.
                                                |   |__negative regulation of plant epidermal cell differentiation(+)
                                                |   |__negative regulation of skeletal muscle cell differentiation(+)
                                                |   |__negative regulation of sorocarp spore cell differentiation
                                                |   |__negative regulation of sorocarp stalk cell differentiation
                                                |   |__negative regulation of spermatid nuclear differentiation
                                                |   |__negative regulation of stem cell differentiation(+) 11 rec.
                                                |   |__negative regulation of synergid differentiation
                                                |   |__negative regulation of tendon cell differentiation
                                                |   |__negative regulation of transdifferentiation
                                                |   |__negative regulation of vasculogenesis
                                                |__negative regulation of cell division 1 rec.
                                                |   |__negative regulation of asymmetric cell division(+)
                                                |   |__negative regulation of cell budding
                                                |   |__negative regulation of cytokinesis(+) 1 rec.
                                                |   |__negative regulation of somatic stem cell division
                                                |__negative regulation of cell growth 19 rec.
                                                |   |__negative regulation of axon extension(+) 5 rec.
                                                |   |__negative regulation of cell growth involved in cardiac muscle cell development
                                                |   |__negative regulation of cell growth involved in contact inhibition
                                                |   |__negative regulation of chondrocyte hypertrophy
                                                |   |__negative regulation of collateral sprouting(+)
                                                |   |__negative regulation of dendrite extension
                                                |   |__negative regulation of direction of cell growth
                                                |   |__negative regulation of pseudohyphal growth
                                                |   |__negative regulation of root hair elongation
                                                |   |__negative regulation of sprouting of injured axon(+)
                                                |   |__negative regulation of unidimensional cell growth(+)
                                                |__negative regulation of cell killing
                                                |   |__negative regulation of complement-dependent cytotoxicity
                                                |   |__negative regulation of killing of cells of another organism(+)
                                                |   |__negative regulation of leukocyte mediated cytotoxicity(+)
                                                |__negative regulation of cell motility 12 rec.
                                                |   |__negative regulation of amoeboid sperm motility
                                                |   |__negative regulation of bacterial-type flagellum-dependent cell motility
                                                |   |__negative regulation of cell migration(+) 12 rec.
                                                |   |__negative regulation of cilium-dependent cell motility(+)
                                                |__negative regulation of cell population proliferation 74 rec.
                                                |   |__negative regulation of cardiac muscle cell proliferation
                                                |   |__negative regulation of cell proliferation in bone marrow
                                                |   |__negative regulation of cell proliferation involved in compound eye morphogenesis
                                                |   |__negative regulation of cell proliferation involved in contact inhibition
                                                |   |__negative regulation of cell proliferation involved in heart morphogenesis(+)
                                                |   |__negative regulation of cell proliferation involved in kidney development(+)
                                                |   |__negative regulation of chondrocyte proliferation
                                                |   |__negative regulation of chorionic trophoblast cell proliferation
                                                |   |__negative regulation of epithelial cell proliferation(+) 2 rec.
                                                |   |__negative regulation of fat cell proliferation(+) 1 rec.
                                                |   |__negative regulation of fibroblast proliferation(+)
                                                |   |__negative regulation of germ cell proliferation(+) 2 rec.
                                                |   |__negative regulation of glial cell proliferation(+) 7 rec.
                                                |   |__negative regulation of growth plate cartilage chondrocyte proliferation
                                                |   |__negative regulation of hair follicle cell proliferation
                                                |   |__negative regulation of hemocyte proliferation 7 rec.
                                                |   |__negative regulation of leukocyte proliferation(+)
                                                |   |__negative regulation of mammary stem cell proliferation
                                                |   |__negative regulation of mesenchymal cell proliferation(+)
                                                |   |__negative regulation of myoblast proliferation(+)
                                                |   |__negative regulation of neural precursor cell proliferation(+) 21 rec.
                                                |   |__negative regulation of osteoblast proliferation
                                                |   |__negative regulation of skeletal muscle cell proliferation(+)
                                                |   |__negative regulation of smooth muscle cell proliferation(+)
                                                |   |__negative regulation of stem cell proliferation(+) 6 rec.
                                                |   |__negative regulation of trophectodermal cell proliferation
                                                |__negative regulation of cell wall organization or biogenesis
                                                |   |__negative regulation of secondary cell wall biogenesis
                                                |__negative regulation of cellular component organization 160 rec.
                                                |   |__negative regulation of adherens junction organization 1 rec.
                                                |   |__negative regulation of barbed-end actin filament capping
                                                |   |__negative regulation of blood microparticle formation(+)
                                                |   |__negative regulation of capsule organization
                                                |   |__negative regulation of cell junction assembly(+) 45 rec.
                                                |   |__negative regulation of cell projection organization(+) 26 rec.
                                                |   |__negative regulation of cell septum assembly(+)
                                                |   |__negative regulation of cell-substrate junction organization(+)
                                                |   |__negative regulation of chromatin organization(+) 9 rec.
                                                |   |__negative regulation of endocytosis(+) 5 rec.
                                                |   |__negative regulation of erythrocyte enucleation
                                                |   |__negative regulation of extracellular matrix organization(+) 2 rec.
                                                |   |__negative regulation of fusion of sperm to egg plasma membrane
                                                |   |__negative regulation of fusion of virus membrane with host plasma membrane
                                                |   |__negative regulation of hyaluranon cable assembly
                                                |   |__negative regulation of inclusion body assembly(+)
                                                |   |__negative regulation of integrin biosynthetic process(+)
                                                |   |__negative regulation of iron-sulfur cluster assembly(+)
                                                |   |__negative regulation of membrane invagination(+)
                                                |   |__negative regulation of membrane tubulation
                                                |   |__negative regulation of mitotic nuclear envelope disassembly
                                                |   |__negative regulation of organelle organization(+) 71 rec.
                                                |   |__negative regulation of phospholipid translocation(+)
                                                |   |__negative regulation of plasma lipoprotein oxidation
                                                |   |__negative regulation of plasma membrane raft polarization
                                                |   |__negative regulation of plasma membrane repair
                                                |   |__negative regulation of protein-containing complex assembly(+) 24 rec.
                                                |   |__negative regulation of protein-containing complex disassembly(+) 24 rec.
                                                |   |__negative regulation of supramolecular fiber organization(+) 37 rec.
                                                |   |__negative regulation of synapse organization(+) 46 rec.
                                                |   |__negative regulation of synapse structural plasticity
                                                |   |__negative regulation of synaptic vesicle membrane organization(+) 1 rec.
                                                |   |__negative regulation of syncytium formation by plasma membrane fusion(+)
                                                |   |__negative regulation of t-circle formation 1 rec.
                                                |   |__negative regulation of terminal button organization
                                                |   |__negative regulation of tight junction disassembly
                                                |   |__negative regulation of very-low-density lipoprotein particle remodeling
                                                |   |__negative regulation of vitellogenesis
                                                |__negative regulation of cellular hyperosmotic salinity response
                                                |__negative regulation of cellular response to alcohol 3 rec.
                                                |   |__negative regulation of abscisic acid-activated signaling pathway
                                                |   |__negative regulation of ecdysone receptor signaling pathway 3 rec.
                                                |__negative regulation of cellular response to alkaline pH
                                                |__negative regulation of cellular response to amino acid starvation
                                                |__negative regulation of cellular response to caffeine
                                                |__negative regulation of cellular response to drug
                                                |__negative regulation of cellular response to gamma radiation
                                                |__negative regulation of cellular response to heat
                                                |__negative regulation of cellular response to hypoxia 1 rec.
                                                |   |__negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
                                                |   |__negative regulation of hypoxia-inducible factor-1alpha signaling pathway
                                                |__negative regulation of cellular response to insulin stimulus 32 rec.
                                                |   |__negative regulation of insulin receptor signaling pathway(+) 32 rec.
                                                |__negative regulation of cellular response to iron ion starvation
                                                |__negative regulation of cellular response to manganese ion
                                                |__negative regulation of cellular response to nitrogen starvation
                                                |__negative regulation of cellular response to oxidative stress 2 rec.
                                                |   |__negative regulation of removal of superoxide radicals 1 rec.
                                                |__negative regulation of cellular response to oxidopamine
                                                |__negative regulation of cellular response to phosphate starvation
                                                |__negative regulation of cellular response to testosterone stimulus
                                                |__negative regulation of cellular response to very-low-density lipoprotein particle stimulus
                                                |__negative regulation of cellular response to X-ray
                                                |__negative regulation of cellular senescence 3 rec.
                                                |__negative regulation of cilium movement
                                                |   |__negative regulation of flagellated sperm motility
                                                |__negative regulation of cytolysis
                                                |__negative regulation of dense core granule biogenesis
                                                |__negative regulation of establishment of bipolar cell polarity
                                                |__negative regulation of establishment of competence for transformation
                                                |__negative regulation of establishment or maintenance of cell polarity regulating cell shape
                                                |   |__negative regulation of establishment of cell polarity regulating cell shape
                                                |   |__negative regulation of establishment or maintenance of bipolar cell polarity regulating cell shape(+)
                                                |__negative regulation of hepatic stellate cell contraction
                                                |__negative regulation of horizontal cell localization
                                                |__negative regulation of intracellular transport 12 rec.
                                                |   |__negative regulation of anterograde axonal transport of mitochondrion
                                                |   |__negative regulation of calcium ion import into sarcoplasmic reticulum
                                                |   |__negative regulation of cargo loading into COPII-coated vesicle
                                                |   |__negative regulation of dense core granule transport(+)
                                                |   |__negative regulation of early endosome to late endosome transport
                                                |   |__negative regulation of endocytic recycling(+) 2 rec.
                                                |   |__negative regulation of intracellular lipid transport(+)
                                                |   |__negative regulation of intracellular protein transport(+) 7 rec.
                                                |   |__negative regulation of intraciliary anterograde transport
                                                |   |__negative regulation of intraciliary retrograde transport
                                                |   |__negative regulation of nuclear migration along microtubule(+)
                                                |   |__negative regulation of nucleocytoplasmic transport(+) 8 rec.
                                                |   |__negative regulation of retrograde axon cargo transport(+)
                                                |   |__negative regulation of retrograde transport, endosome to Golgi
                                                |   |__negative regulation of vacuolar transport(+)
                                                |   |__negative regulation of vesicle transport along microtubule(+)
                                                |__negative regulation of lipid storage 13 rec.
                                                |   |__negative regulation of cholesterol storage
                                                |   |__negative regulation of triglyceride storage 4 rec.
                                                |__negative regulation of melanosome transport
                                                |__negative regulation of metabolic process 1055 rec.
                                                |   |__negative regulation of amide metabolic process(+) 1 rec.
                                                |   |__negative regulation of amine metabolic process(+) 1 rec.
                                                |   |__negative regulation of amino acid metabolic process(+)
                                                |   |__negative regulation of anthocyanin metabolic process(+)
                                                |   |__negative regulation of bioluminescence
                                                |   |__negative regulation of biosynthetic process(+) 943 rec.
                                                |   |__negative regulation of carbohydrate metabolic process(+) 5 rec.
                                                |   |__negative regulation of catabolic process(+) 78 rec.
                                                |   |__negative regulation of cellular respiration(+) 2 rec.
                                                |   |__negative regulation of cobalamin metabolic process
                                                |   |__negative regulation of cold-induced thermogenesis
                                                |   |__negative regulation of collagen metabolic process(+)
                                                |   |__negative regulation of fermentation(+)
                                                |   |__negative regulation of hormone metabolic process(+) 6 rec.
                                                |   |__negative regulation of lipid metabolic process(+) 15 rec.
                                                |   |__negative regulation of macromolecule metabolic process(+) 1000 rec.
                                                |   |__negative regulation of melanization defense response(+) 5 rec.
                                                |   |__negative regulation of metabolic activity involved in hibernation
                                                |   |__negative regulation of nitrogen cycle metabolic process(+)
                                                |   |__negative regulation of nucleobase-containing compound metabolic process(+) 383 rec.
                                                |   |__negative regulation of organofluorine metabolic process
                                                |   |__negative regulation of phosphorus metabolic process(+) 3 rec.
                                                |   |__negative regulation of photosynthesis(+)
                                                |   |__negative regulation of reactive oxygen species metabolic process(+) 7 rec.
                                                |   |__negative regulation of respiratory burst(+)
                                                |   |__negative regulation of siRNA processing
                                                |   |__negative regulation of small molecule metabolic process(+) 4 rec.
                                                |__negative regulation of muscle filament sliding
                                                |__negative regulation of myelination
                                                |__negative regulation of myofibroblast contraction
                                                |__negative regulation of phenotypic switching
                                                |   |__negative regulation of cell differentiation involved in phenotypic switching(+)
                                                |__negative regulation of plus-end directed microtubule sliding
                                                |__negative regulation of pre-B cell receptor expression
                                                |__negative regulation of programmed cell death 138 rec.
                                                |   |__negative regulation of apoptotic process(+) 126 rec.
                                                |   |__negative regulation of autophagic cell death
                                                |   |__negative regulation of cornification
                                                |   |__negative regulation of ferroptosis
                                                |   |__negative regulation of hydrogen peroxide-mediated programmed cell death(+)
                                                |   |__negative regulation of plant-type hypersensitive response
                                                |   |__negative regulation of programmed necrotic cell death(+) 1 rec.
                                                |   |__negative regulation of retinal cell programmed cell death(+) 7 rec.
                                                |__negative regulation of protein folding
                                                |   |__negative regulation of protein refolding
                                                |__negative regulation of protein localization to membrane 3 rec.
                                                |   |__negative regulation of protein localization to basolateral plasma membrane
                                                |   |__negative regulation of protein localization to ciliary membrane
                                                |   |__negative regulation of protein localization to plasma membrane(+) 3 rec.
                                                |   |__negative regulation of protein targeting to vacuolar membrane
                                                |   |__negative regulation of receptor clustering(+)
                                                |   |__negative regulation of t-SNARE clustering
                                                |__negative regulation of protein targeting to membrane
                                                |   |__negative regulation of protein targeting to vacuolar membrane
                                                |__negative regulation of response to endoplasmic reticulum stress 5 rec.
                                                |   |__negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(+) 1 rec.
                                                |   |__negative regulation of endoplasmic reticulum unfolded protein response(+) 2 rec.
                                                |   |__negative regulation of ERAD pathway 2 rec.
                                                |__negative regulation of ribonucleoprotein complex localization
                                                |   |__negative regulation of ribosomal subunit export from nucleus(+)
                                                |   |__negative regulation of tRNA export from nucleus
                                                |__negative regulation of ribosome biogenesis 1 rec.
                                                |   |__negative regulation of ribosomal subunit export from nucleus(+)
                                                |   |__negative regulation of rRNA processing
                                                |__negative regulation of secretion by cell 16 rec.
                                                |   |__negative regulation of aspartate secretion
                                                |   |__negative regulation of catecholamine secretion(+)
                                                |   |__negative regulation of exocytosis(+) 3 rec.
                                                |   |__negative regulation of extracellular matrix constituent secretion
                                                |   |__negative regulation of glutamate secretion(+) 1 rec.
                                                |   |__negative regulation of hormone secretion(+) 7 rec.
                                                |   |__negative regulation of neurotransmitter secretion(+) 3 rec.
                                                |   |__negative regulation of prostaglandin secretion
                                                |   |__negative regulation of protein secretion(+) 4 rec.
                                                |   |__negative regulation of serotonin secretion
                                                |__negative regulation of septum digestion after cytokinesis
                                                |__negative regulation of sequestering of calcium ion 10 rec.
                                                |   |__release of sequestered calcium ion into cytosol(+) 10 rec.
                                                |__negative regulation of single-species biofilm formation
                                                |   |__negative regulation of single-species biofilm formation in or on host organism
                                                |   |__negative regulation of single-species biofilm formation on inanimate substrate
                                                |__negative regulation of spore germination
                                                |   |__negative regulation of encysted zoospore germination
                                                |__negative regulation of stomatal opening
                                                |__negative regulation of synaptic vesicle transport
                                                |   |__negative regulation of anterograde synaptic vesicle transport
                                                |__negative regulation of transcytosis
                                                |__negative regulation of transmembrane transport 1 rec.
                                                |   |__negative regulation of (R)-carnitine transmembrane transport
                                                |   |__negative regulation of D-aspartate import across plasma membrane
                                                |   |__negative regulation of D-glucose transmembrane transport(+)
                                                |   |__negative regulation of dipeptide transmembrane transport
                                                |   |__negative regulation of gluconate transmembrane transport
                                                |   |__negative regulation of glycerol transport
                                                |   |__negative regulation of glycine import across plasma membrane
                                                |   |__negative regulation of L-arginine import across plasma membrane
                                                |   |__negative regulation of L-glutamate import across plasma membrane(+)
                                                |   |__negative regulation of L-glutamine import across plasma membrane
                                                |   |__negative regulation of L-leucine import across plasma membrane(+)
                                                |   |__negative regulation of L-lysine import across plasma membrane
                                                |   |__negative regulation of L-methionine import across plasma membrane
                                                |   |__negative regulation of L-threonine import across plasma membrane
                                                |   |__negative regulation of L-tyrosine import across plasma membrane
                                                |   |__negative regulation of long-chain fatty acid import across plasma membrane
                                                |   |__negative regulation of monoatomic ion transmembrane transport(+) 1 rec.
                                                |   |__negative regulation of phosphate transmembrane transport
                                                |   |__negative regulation of polyamine transmembrane transport
                                                |   |__negative regulation of post-translational protein targeting to membrane, translocation
                                                |   |__negative regulation of proline import across plasma membrane(+)
                                                |   |__negative regulation of uracil import across plasma membrane
                                                |   |__negative regulation of xenobiotic detoxification by transmembrane export across the plasma membrane
                                                |__negative regulation of vascular associated smooth muscle cell dedifferentiation
                                                |__negative regulation of vesicle docking
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Is a negative regulation of biological process
regulation of cellular process
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Synonyms
  • "down regulation of cellular process" EXACT
    "down-regulation of cellular process" EXACT
    "downregulation of cellular process" EXACT
    "inhibition of cellular process" NARROW
    "negative regulation of cellular physiological process" EXACT
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