FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term negative regulation of protein secretion ID (Ontology) GO:0050709 (Gene Ontology)
Definition Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell.
Also Known As "down regulation of protein secretion" ; "down-regulation of protein secretion" ; "downregulation of protein secretion"
Comment
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS       2
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Genes
 negative regulation of protein secretion (all annotations which use CV term, excluding "NOT" statements)       2
     involved_in | negative regulation of protein secretion       2
Spanning Tree (Parents/Children)
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protein secretion
 |__regulation of protein secretion___________________________
negative regulation of cellular process                       |
 |__negative regulation of secretion by cell__________________|
negative regulation of secretion                              |
 |__negative regulation of secretion by cell__________________|
negative regulation of transport                              |
 |__negative regulation of protein transport__________________|
regulation of protein transport                               |
 |__regulation of protein secretion___________________________|
 |__negative regulation of protein transport__________________|
regulation of secretion by cell                               |
 |__regulation of protein secretion___________________________|
 |__negative regulation of secretion by cell__________________|
negative regulation of protein localization                   |
 |__negative regulation of protein transport__________________|
negative regulation of establishment of protein localization  |
 |__negative regulation of protein transport__________________|
                                                              negative regulation of protein secretion  4 rec.
                                                               |__negative regulation of adiponectin secretion
                                                               |__negative regulation of BMP secretion
                                                               |__negative regulation of insulin secretion 1 rec.
                                                               |   |__negative regulation of insulin secretion involved in cellular response to glucose stimulus
                                                               |__negative regulation of matrix metallopeptidase secretion
                                                               |__negative regulation of pancreatic amylase secretion
                                                               |__negative regulation of pancreatic trypsinogen secretion
                                                               |__negative regulation of prolactin secretion
                                                               |__negative regulation of renin secretion into blood stream
                                                               |__negative regulation of secretion of lysosomal enzymes
                                                               |__negative regulation of Wnt protein secretion 1 rec.
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Is a regulation of protein secretion
negative regulation of protein transport
negative regulation of secretion by cell
Part of
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Synonyms
  • "down regulation of protein secretion" EXACT
    "down-regulation of protein secretion" EXACT
    "downregulation of protein secretion" EXACT
    "inhibition of protein secretion" NARROW
Secondary IDs
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