FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term regulation of immune response ID (Ontology) GO:0050776 (Gene Ontology)
Definition Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
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Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS      19
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Genes
 regulation of immune response (all annotations which use CV term, excluding "NOT" statements)      19
     involved_in | regulation of immune response      19
Spanning Tree (Parents/Children)
Only view relationship: 
regulation of biological process
 |__regulation of immune system process__
 |__regulation of response to stimulus___|
                                         regulation of immune response  249 rec.
                                          |__immune response-regulating signaling pathway 101 rec.
                                          |   |__immune response-activating signaling pathway(+) 101 rec.
                                          |   |__immune response-inhibiting signal transduction(+)
                                          |   |__immune response-regulating cell surface receptor signaling pathway(+) 3 rec.
                                          |__negative regulation of immune response 67 rec.
                                          |   |__negative regulation of adaptive immune response(+)
                                          |   |__negative regulation of basophil degranulation
                                          |   |__negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response
                                          |   |__negative regulation of eosinophil degranulation
                                          |   |__negative regulation of gamma-delta T cell activation involved in immune response
                                          |   |__negative regulation of humoral immune response(+) 27 rec.
                                          |   |__negative regulation of immune response to tumor cell(+)
                                          |   |__negative regulation of inflammatory response to antigenic stimulus(+)
                                          |   |__negative regulation of innate immune response(+) 39 rec.
                                          |   |__negative regulation of mast cell activation involved in immune response
                                          |   |__negative regulation of memory T cell differentiation
                                          |   |__negative regulation of natural killer cell differentiation involved in immune response
                                          |   |__negative regulation of natural killer cell proliferation involved in immune response
                                          |   |__negative regulation of neutrophil degranulation
                                          |   |__negative regulation of plasma cell differentiation
                                          |   |__negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
                                          |   |__negative regulation of T-helper cell differentiation(+)
                                          |   |__negative regulation of type 2 immune response(+)
                                          |__positive regulation of immune response 182 rec.
                                          |   |__activation of immune response(+) 104 rec.
                                          |   |__positive regulation of adaptive immune response(+)
                                          |   |__positive regulation of antigen receptor-mediated signaling pathway(+)
                                          |   |__positive regulation of basophil degranulation
                                          |   |__positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response
                                          |   |__positive regulation of eosinophil degranulation
                                          |   |__positive regulation of Fc receptor mediated stimulatory signaling pathway(+)
                                          |   |__positive regulation of gamma-delta T cell activation involved in immune response
                                          |   |__positive regulation of humoral immune response(+) 64 rec.
                                          |   |__positive regulation of immune response to tumor cell(+)
                                          |   |__positive regulation of inflammatory response to antigenic stimulus(+)
                                          |   |__positive regulation of innate immune response(+) 138 rec.
                                          |   |__positive regulation of mast cell activation involved in immune response
                                          |   |__positive regulation of memory T cell differentiation
                                          |   |__positive regulation of natural killer cell differentiation involved in immune response
                                          |   |__positive regulation of neutrophil degranulation
                                          |   |__positive regulation of plasma cell differentiation
                                          |   |__positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
                                          |   |__positive regulation of T-helper cell differentiation(+)
                                          |   |__positive regulation of type 2 immune response(+)
                                          |__regulation of adaptive immune response
                                          |   |__negative regulation of adaptive immune response(+)
                                          |   |__positive regulation of adaptive immune response(+)
                                          |   |__regulation of adaptive immune effector response(+)
                                          |   |__regulation of adaptive immune memory response(+)
                                          |   |__regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains(+)
                                          |__regulation of antigen receptor-mediated signaling pathway
                                          |   |__negative regulation of antigen receptor-mediated signaling pathway(+)
                                          |   |__positive regulation of antigen receptor-mediated signaling pathway(+)
                                          |   |__regulation of B cell receptor signaling pathway(+)
                                          |   |__regulation of T cell receptor signaling pathway(+)
                                          |__regulation of basophil degranulation
                                          |   |__negative regulation of basophil degranulation
                                          |   |__positive regulation of basophil degranulation
                                          |__regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response
                                          |   |__negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response
                                          |   |__positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response
                                          |__regulation of eosinophil degranulation
                                          |   |__negative regulation of eosinophil degranulation
                                          |   |__positive regulation of eosinophil degranulation
                                          |__regulation of Fc receptor mediated stimulatory signaling pathway
                                          |   |__positive regulation of Fc receptor mediated stimulatory signaling pathway(+)
                                          |   |__regulation of Fc-gamma receptor signaling pathway involved in phagocytosis(+)
                                          |__regulation of gamma-delta T cell activation involved in immune response
                                          |   |__negative regulation of gamma-delta T cell activation involved in immune response
                                          |   |__positive regulation of gamma-delta T cell activation involved in immune response
                                          |__regulation of humoral immune response 95 rec.
                                          |   |__negative regulation of humoral immune response(+) 27 rec.
                                          |   |__positive regulation of humoral immune response(+) 64 rec.
                                          |   |__regulation of antimicrobial humoral response(+) 92 rec.
                                          |   |__regulation of complement activation(+)
                                          |   |__regulation of humoral immune response mediated by circulating immunoglobulin(+)
                                          |__regulation of immune response to tumor cell
                                          |   |__negative regulation of immune response to tumor cell(+)
                                          |   |__positive regulation of immune response to tumor cell(+)
                                          |   |__regulation of natural killer cell mediated immune response to tumor cell(+)
                                          |   |__regulation of T cell mediated immune response to tumor cell(+)
                                          |   |__regulation of tolerance induction to tumor cell(+)
                                          |__regulation of inflammatory response to antigenic stimulus
                                          |   |__negative regulation of inflammatory response to antigenic stimulus(+)
                                          |   |__positive regulation of inflammatory response to antigenic stimulus(+)
                                          |   |__regulation of acute inflammatory response to antigenic stimulus(+)
                                          |   |__regulation of chronic inflammatory response to antigenic stimulus(+)
                                          |__regulation of innate immune response 177 rec.
                                          |   |__negative regulation of innate immune response(+) 39 rec.
                                          |   |__positive regulation of innate immune response(+) 138 rec.
                                          |   |__regulation of age-related resistance(+)
                                          |   |__regulation of antifungal innate immune response(+) 2 rec.
                                          |   |__regulation of complement activation, alternative pathway(+)
                                          |   |__regulation of complement activation, lectin pathway(+)
                                          |   |__regulation of innate immunity memory response(+)
                                          |   |__regulation of melanization defense response(+) 13 rec.
                                          |   |__regulation of natural killer cell mediated immunity(+)
                                          |   |__regulation of pattern recognition receptor signaling pathway(+) 69 rec.
                                          |   |__regulation of plant-type hypersensitive response(+)
                                          |   |__regulation of respiratory burst involved in inflammatory response(+)
                                          |   |__regulation of response to type II interferon(+)
                                          |   |__regulation of type I interferon-mediated signaling pathway(+)
                                          |__regulation of mast cell activation involved in immune response
                                          |   |__negative regulation of mast cell activation involved in immune response
                                          |   |__positive regulation of mast cell activation involved in immune response
                                          |__regulation of memory T cell differentiation
                                          |   |__negative regulation of memory T cell differentiation
                                          |   |__positive regulation of memory T cell differentiation
                                          |__regulation of natural killer cell proliferation involved in immune response
                                          |   |__negative regulation of natural killer cell proliferation involved in immune response
                                          |   |__positive regulation of natural killer cell proliferation involved in immune response
                                          |__regulation of neutrophil degranulation
                                          |   |__negative regulation of neutrophil degranulation
                                          |   |__positive regulation of neutrophil degranulation
                                          |__regulation of plasma cell differentiation
                                          |   |__negative regulation of plasma cell differentiation
                                          |   |__positive regulation of plasma cell differentiation
                                          |__regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
                                          |   |__negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
                                          |   |__positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
                                          |__regulation of T-helper cell differentiation
                                          |   |__negative regulation of T-helper cell differentiation(+)
                                          |   |__positive regulation of T-helper cell differentiation(+)
                                          |   |__regulation of T-helper 1 cell differentiation(+)
                                          |   |__regulation of T-helper 2 cell differentiation(+)
                                          |   |__regulation of T-helper 17 cell differentiation(+)
                                          |__regulation of type 2 immune response
                                              |__negative regulation of type 2 immune response(+)
                                              |__positive regulation of type 2 immune response(+)
                                              |__regulation of T-helper 2 cell cytokine production(+)
                                              |__regulation of T-helper 2 cell differentiation(+)
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Is a regulation of immune system process
regulation of response to stimulus
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Reactome:R-HSA-198933 "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"