FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
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Term negative regulation of developmental process ID (Ontology) GO:0051093 (Gene Ontology)
Definition Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
Also Known As "down regulation of developmental process" ; "down-regulation of developmental process" ; "downregulation of developmental process"
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developmental process
 |__regulation of developmental process________
regulation of biological process               |
 |__negative regulation of biological process__|
 |__regulation of developmental process________|
                                               negative regulation of developmental process  216 rec.
                                                |__negative regulation of adipose tissue development
                                                |__negative regulation of age-related resistance
                                                |__negative regulation of aggregation involved in sorocarp development
                                                |__negative regulation of animal organ morphogenesis
                                                |   |__negative regulation of nematode pharynx morphogenesis
                                                |   |__negative regulation of odontogenesis(+)
                                                |   |__negative regulation of otic vesicle morphogenesis
                                                |__negative regulation of anterior head development
                                                |__negative regulation of apical ectodermal ridge formation
                                                |__negative regulation of apoptotic process involved in development 2 rec.
                                                |   |__negative regulation of apoptotic process involved in metanephric collecting duct development
                                                |   |__negative regulation of apoptotic process involved in metanephric nephron tubule development
                                                |   |__negative regulation of apoptotic process involved in morphogenesis(+)
                                                |   |__negative regulation of B cell deletion(+)
                                                |   |__negative regulation of mesenchymal cell apoptotic process involved in metanephros development(+)
                                                |   |__negative regulation of nurse cell apoptotic process 2 rec.
                                                |__negative regulation of appressorium formation
                                                |__negative regulation of basement membrane assembly involved in embryonic body morphogenesis
                                                |__negative regulation of biomineral tissue development
                                                |   |__negative regulation of bone mineralization(+)
                                                |   |__negative regulation of shell calcification
                                                |   |__negative regulation of tooth mineralization(+)
                                                |__negative regulation of blood microparticle formation
                                                |   |__negative regulation of endothelial microparticle formation
                                                |__negative regulation of blood vessel remodeling
                                                |   |__negative regulation of pulmonary blood vessel remodeling
                                                |__negative regulation of bone development
                                                |__negative regulation of bone trabecula formation
                                                |__negative regulation of branching morphogenesis of a nerve
                                                |__negative regulation of cardiac chamber formation
                                                |   |__negative regulation of cardiac ventricle formation
                                                |__negative regulation of cardiac chamber morphogenesis
                                                |__negative regulation of cardiac ventricle development
                                                |   |__negative regulation of cardiac ventricle formation
                                                |__negative regulation of cartilage development
                                                |   |__negative regulation of chondrocyte differentiation(+)
                                                |__negative regulation of cell differentiation 97 rec.
                                                |   |__maintenance of animal organ identity(+)
                                                |   |__maintenance of imaginal histoblast diploidy 1 rec.
                                                |   |__maintenance of plant organ identity(+)
                                                |   |__negative regulation of antipodal cell differentiation
                                                |   |__negative regulation of cardiac endothelial to mesenchymal transition
                                                |   |__negative regulation of cardiocyte differentiation(+) 5 rec.
                                                |   |__negative regulation of cell development(+) 45 rec.
                                                |   |__negative regulation of cell differentiation involved in embryonic placenta development
                                                |   |__negative regulation of cell differentiation involved in phenotypic switching(+)
                                                |   |__negative regulation of cell differentiation involved in stem cell population maintenance
                                                |   |__negative regulation of cell fate commitment(+) 21 rec.
                                                |   |__negative regulation of chondrocyte differentiation(+)
                                                |   |__negative regulation of embryo sac central cell differentiation
                                                |   |__negative regulation of embryo sac egg cell differentiation
                                                |   |__negative regulation of endodermal cell differentiation(+)
                                                |   |__negative regulation of epithelial cell differentiation(+)
                                                |   |__negative regulation of epithelial to mesenchymal transition(+)
                                                |   |__negative regulation of fat cell differentiation(+)
                                                |   |__negative regulation of hematopoietic progenitor cell differentiation(+) 1 rec.
                                                |   |__negative regulation of hemocyte differentiation(+) 19 rec.
                                                |   |__negative regulation of macrophage derived foam cell differentiation
                                                |   |__negative regulation of mesodermal cell differentiation(+)
                                                |   |__negative regulation of metanephric DCT cell differentiation
                                                |   |__negative regulation of muscle cell differentiation(+) 2 rec.
                                                |   |__negative regulation of myeloid cell differentiation(+)
                                                |   |__negative regulation of myoblast differentiation(+)
                                                |   |__negative regulation of myofibroblast differentiation
                                                |   |__negative regulation of neuron differentiation(+) 15 rec.
                                                |   |__negative regulation of osteoblast differentiation
                                                |   |__negative regulation of pigment cell differentiation(+) 1 rec.
                                                |   |__negative regulation of plant epidermal cell differentiation(+)
                                                |   |__negative regulation of skeletal muscle cell differentiation(+)
                                                |   |__negative regulation of sorocarp spore cell differentiation
                                                |   |__negative regulation of sorocarp stalk cell differentiation
                                                |   |__negative regulation of spermatid nuclear differentiation
                                                |   |__negative regulation of stem cell differentiation(+) 11 rec.
                                                |   |__negative regulation of synergid differentiation
                                                |   |__negative regulation of tendon cell differentiation
                                                |   |__negative regulation of transdifferentiation
                                                |   |__negative regulation of vasculogenesis
                                                |__negative regulation of chitin-based cuticle tanning
                                                |   |__negative regulation of adult chitin-containing cuticle pigmentation
                                                |__negative regulation of conidiophore stalk development
                                                |__negative regulation of cuticle pigmentation
                                                |   |__negative regulation of adult chitin-containing cuticle pigmentation
                                                |__negative regulation of dendrite development
                                                |__negative regulation of dendritic spine development
                                                |   |__negative regulation of dendritic spine morphogenesis
                                                |__negative regulation of developmental growth 91 rec.
                                                |   |__negative regulation of axon extension(+) 5 rec.
                                                |   |__negative regulation of branch elongation involved in ureteric bud branching
                                                |   |__negative regulation of bud outgrowth involved in lung branching
                                                |   |__negative regulation of cardiac muscle tissue regeneration
                                                |   |__negative regulation of chondrocyte hypertrophy
                                                |   |__negative regulation of collateral sprouting(+)
                                                |   |__negative regulation of convergent extension involved in axis elongation(+)
                                                |   |__negative regulation of dendrite extension
                                                |   |__negative regulation of developmental vegetative growth
                                                |   |__negative regulation of epithelium regeneration
                                                |   |__negative regulation of imaginal disc growth 14 rec.
                                                |   |__negative regulation of multicellular organism growth 13 rec.
                                                |   |__negative regulation of organ growth(+) 19 rec.
                                                |   |__negative regulation of root hair elongation
                                                |   |__negative regulation of skeletal muscle tissue growth
                                                |   |__negative regulation of skeletal muscle tissue regeneration(+)
                                                |   |__negative regulation of sprouting of injured axon(+)
                                                |   |__negative regulation of synaptic assembly at neuromuscular junction 43 rec.
                                                |   |__negative regulation of unidimensional cell growth(+)
                                                |__negative regulation of eclosion 1 rec.
                                                |__negative regulation of ectoderm development
                                                |__negative regulation of embryonic camera-type eye development
                                                |__negative regulation of embryonic development
                                                |   |__negative regulation of dermatome development
                                                |   |__negative regulation of gastrulation
                                                |__negative regulation of embryonic skeletal joint development
                                                |__negative regulation of endosperm development
                                                |__negative regulation of entry into reproductive diapause 5 rec.
                                                |__negative regulation of epidermis development
                                                |   |__negative regulation of epidermal cell differentiation(+)
                                                |__negative regulation of epithelial cell proliferation involved in prostate gland development
                                                |__negative regulation of female pigmentation
                                                |__negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation
                                                |__negative regulation of floral organ abscission
                                                |__negative regulation of formation of symbiont germ tube hook structure for appressorium development
                                                |__negative regulation of germ tube formation
                                                |__negative regulation of germinal center formation
                                                |__negative regulation of gonad development
                                                |   |__negative regulation of female gonad development(+)
                                                |   |__negative regulation of male gonad development
                                                |__negative regulation of hair follicle development
                                                |   |__negative regulation of hair follicle maturation(+)
                                                |   |__negative regulation of hair follicle placode formation
                                                |__negative regulation of haustorium mother cell formation
                                                |__negative regulation of heart induction
                                                |__negative regulation of hyphopodium formation
                                                |__negative regulation of imaginal disc-derived leg joint morphogenesis
                                                |__negative regulation of infection cushion formation
                                                |__negative regulation of isotype switching
                                                |   |__negative regulation of isotype switching to IgA isotypes
                                                |   |__negative regulation of isotype switching to IgD isotypes
                                                |   |__negative regulation of isotype switching to IgE isotypes
                                                |   |__negative regulation of isotype switching to IgG isotypes
                                                |__negative regulation of kidney development
                                                |   |__negative regulation of glomerulus development(+)
                                                |   |__negative regulation of mesonephros development(+)
                                                |   |__negative regulation of metanephros development(+)
                                                |   |__negative regulation of nephron tubule epithelial cell differentiation(+)
                                                |__negative regulation of lactation
                                                |__negative regulation of lamellipodium morphogenesis
                                                |__negative regulation of leaf development
                                                |__negative regulation of leaf senescence
                                                |__negative regulation of lung alveolus development
                                                |__negative regulation of lymphangiogenesis
                                                |__negative regulation of male pigmentation 1 rec.
                                                |__negative regulation of mammary stem cell proliferation
                                                |__negative regulation of mating type switching
                                                |__negative regulation of mesenchymal cell proliferation involved in lung development
                                                |__negative regulation of mesenchymal cell proliferation involved in ureter development
                                                |__negative regulation of mesoderm development
                                                |   |__negative regulation of mesoderm formation
                                                |__negative regulation of metanephric comma-shaped body morphogenesis
                                                |__negative regulation of metanephric S-shaped body morphogenesis
                                                |__negative regulation of metanephric ureteric bud development
                                                |__negative regulation of mitochondrial fission 2 rec.
                                                |__negative regulation of mitochondrial fusion 3 rec.
                                                |__negative regulation of morphogenesis of an epithelium
                                                |   |__negative regulation of blood vessel branching
                                                |   |__negative regulation of branching involved in lung morphogenesis(+)
                                                |   |__negative regulation of branching involved in ureteric bud morphogenesis
                                                |   |__negative regulation of convergent extension involved in axis elongation(+)
                                                |   |__negative regulation of convergent extension involved in gastrulation(+)
                                                |   |__negative regulation of endothelial tube morphogenesis
                                                |   |__negative regulation of epiboly involved in gastrulation with mouth forming second
                                                |   |__negative regulation of epithelial tube formation
                                                |   |__negative regulation of heart looping
                                                |   |__negative regulation of otic vesicle morphogenesis
                                                |   |__negative regulation of prostatic bud formation
                                                |__negative regulation of muscle organ development 5 rec.
                                                |   |__negative regulation of somitomeric trunk muscle development
                                                |   |__negative regulation of striated muscle tissue development(+) 1 rec.
                                                |__negative regulation of muscle tissue development 1 rec.
                                                |   |__negative regulation of smooth muscle tissue development
                                                |   |__negative regulation of striated muscle tissue development(+) 1 rec.
                                                |__negative regulation of nematode male tail tip morphogenesis
                                                |__negative regulation of nervous system development 85 rec.
                                                |   |__negative regulation of anterior neural cell fate commitment of the neural plate(+)
                                                |   |__negative regulation of neurogenesis(+) 41 rec.
                                                |   |__negative regulation of synapse assembly(+) 45 rec.
                                                |__negative regulation of neuron projection arborization 5 rec.
                                                |__negative regulation of neuron projection regeneration 3 rec.
                                                |   |__negative regulation of axon regeneration(+) 3 rec.
                                                |__negative regulation of optic nerve formation
                                                |__negative regulation of ovarian follicle development
                                                |__negative regulation of placenta blood vessel development
                                                |__negative regulation of plant organ morphogenesis
                                                |__negative regulation of post-embryonic development 2 rec.
                                                |   |__negative regulation of flower development
                                                |   |__negative regulation of lateral root development
                                                |   |__negative regulation of long-day photoperiodism, flowering
                                                |   |__negative regulation of nematode larval development(+)
                                                |   |__negative regulation of photomorphogenesis
                                                |   |__negative regulation of pupariation 2 rec.
                                                |   |__negative regulation of seed germination
                                                |   |__negative regulation of short-day photoperiodism, flowering
                                                |   |__negative regulation of stomatal complex development
                                                |   |__negative regulation of thermomorphogenesis
                                                |__negative regulation of pre-B cell receptor expression
                                                |__negative regulation of pronephric nephron tubule development
                                                |__negative regulation of retina development in camera-type eye
                                                |   |__negative regulation of neural retina development
                                                |__negative regulation of retinal cell programmed cell death 7 rec.
                                                |   |__negative regulation of compound eye retinal cell programmed cell death 7 rec.
                                                |__negative regulation of salivary gland boundary specification 8 rec.
                                                |   |__negative regulation of adult salivary gland boundary specification
                                                |   |__negative regulation of larval salivary gland boundary specification
                                                |__negative regulation of sclerotium development
                                                |__negative regulation of seed dormancy process
                                                |__negative regulation of seed maturation
                                                |__negative regulation of shoot apical meristem development
                                                |__negative regulation of somatic muscle development
                                                |   |__negative regulation of adult somatic muscle development
                                                |   |__negative regulation of larval somatic muscle development
                                                |__negative regulation of spore germination
                                                |   |__negative regulation of encysted zoospore germination
                                                |__negative regulation of spore-bearing organ development
                                                |   |__negative regulation of aecium development
                                                |   |__negative regulation of ascus development
                                                |   |__negative regulation of basidium development
                                                |   |__negative regulation of conidiophore development(+)
                                                |   |__negative regulation of oogonium development
                                                |   |__negative regulation of sorocarp stalk cell differentiation
                                                |   |__negative regulation of sporangium development(+)
                                                |   |__negative regulation of sporocarp development involved in sexual reproduction(+)
                                                |   |__negative regulation of telium development
                                                |   |__negative regulation of uredinium development
                                                |   |__negative regulation of zygosporangium development
                                                |__negative regulation of sporulation
                                                |   |__negative regulation of conidium formation
                                                |   |__negative regulation of oomycete sporangium development
                                                |   |__negative regulation of sporulation resulting in formation of a cellular spore(+)
                                                |__negative regulation of stem cell population maintenance
                                                |   |__negative regulation of somatic stem cell population maintenance(+)
                                                |__negative regulation of synapse maturation
                                                |__negative regulation of synaptic vesicle lumen acidification
                                                |__negative regulation of syncytium formation by plasma membrane fusion
                                                |   |__negative regulation of macrophage fusion
                                                |   |__negative regulation of myoblast fusion
                                                |__negative regulation of thyroid gland epithelial cell proliferation
                                                |__negative regulation of tolerance induction
                                                |   |__negative regulation of B cell tolerance induction(+)
                                                |   |__negative regulation of central tolerance induction(+)
                                                |   |__negative regulation of lymphocyte anergy(+)
                                                |   |__negative regulation of natural killer cell tolerance induction
                                                |   |__negative regulation of T cell tolerance induction(+)
                                                |   |__negative regulation of tolerance induction dependent upon immune response(+)
                                                |   |__negative regulation of tolerance induction to self antigen
                                                |__negative regulation of tube lumen cavitation
                                                |__negative regulation of vascular associated smooth muscle cell dedifferentiation
                                                |__negative regulation of vasculature development
                                                |   |__negative regulation of blood vessel morphogenesis(+)
                                                |   |__negative regulation of vasculature development involved in avascular cornea development in camera-type eye
                                                |__negative regulation of Wnt signaling pathway involved in heart development
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Is a negative regulation of biological process
regulation of developmental process
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Synonyms
  • "down regulation of developmental process" EXACT
    "down-regulation of developmental process" EXACT
    "downregulation of developmental process" EXACT
    "inhibition of developmental process" NARROW
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