FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ID (Ontology) GO:0051898 (Gene Ontology)
Definition Any process that stops, prevents, or reduces the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction.
Also Known As "negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction" ; "negative regulation of PI3K-PKB/Akt pathway" ; "negative regulation of PI3K/Akt signal transduction" (for all, see Synonyms field below)
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS      11
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 Full annotation statements 
Relevant FlyBase reports
 Genes
 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (all annotations which use CV term, excluding "NOT" statements)      11
     involved_in | negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction      11
Spanning Tree (Parents/Children)
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negative regulation of signal transduction
 |__negative regulation of intracellular signal transduction__________________________
phosphatidylinositol 3-kinase/protein kinase B signal transduction                    |
 |__regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction__|
regulation of intracellular signal transduction                                       |
 |__regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction__|
 |__negative regulation of intracellular signal transduction__________________________|
                                                                                      negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  11 rec.
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Is a regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
negative regulation of intracellular signal transduction
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Synonyms
  • "down regulation of protein kinase B signaling cascade" RELATED
    "down-regulation of protein kinase B signaling cascade" RELATED
    "downregulation of protein kinase B signaling cascade" RELATED
    "inhibition of protein kinase B signaling cascade" NARROW
    "negative regulation of AKT signaling cascade" RELATED
    "negative regulation of AKT signalling cascade" RELATED
    "negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction" EXACT
    "negative regulation of PI3K-PKB/Akt pathway" EXACT
    "negative regulation of PI3K/Akt signal transduction" EXACT
    "negative regulation of PI3K/PKB signal transduction" EXACT
    "negative regulation of PKB signaling cascade" RELATED
    "negative regulation of PKB signalling cascade" RELATED
    "negative regulation of protein kinase B signaling" RELATED
    "negative regulation of protein kinase B signaling cascade" RELATED
    "negative regulation of protein kinase B signalling cascade" RELATED
Secondary IDs
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