FB2025_05 , released December 11, 2025

CV Term Report

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General Information
Term	membrane depolarization	ID (Ontology)	GO:0051899 (Gene Ontology)
Definition	The process in which membrane potential decreases with respect to its steady-state potential, usually from negative potential to a more positive potential. For example, the initial depolarization during the rising phase of an action potential is in the direction from the negative steady-state resting potential towards the positive membrane potential that will be the peak of the action potential.
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Spanning Tree (Parents/Children)

  regulation of biological quality
   |__regulation of membrane potential
       |__membrane depolarization  7 rec.
           |__membrane depolarization during action potential 3 rec.
           |   |__membrane depolarization during cardiac muscle cell action potential(+)
           |__mitochondrial depolarization 2 rec.
           |__regulation of vascular associated smooth muscle cell membrane depolarization

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Relationships
Is a	regulation of membrane potential
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Synonyms & Secondary IDs
Synonyms

Secondary IDs

External Crossreferences & Linkouts
	Reactome:R-HSA-112308 "Presynaptic depolarization and calcium channel opening"