FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
Help Close All Open All
General Information
Term lysine biosynthetic process via alpha-aminoadipate and saccharopine ID (Ontology) GO:0051975 (Gene Ontology)
Definition The chemical reactions and pathways resulting in the formation of lysine via the intermediates alpha-aminoadipic acid and saccharopine. This pathway is used by yeast and fungi to synthesize the essential amino acid L-lysine, and pathway intermediates are often incorporated into secondary metabolic processes. The pathway proceeds as follows: alpha-ketoglutarate is converted to homocitrate, which is metabolized to 3-carboxyhex-2-enedioate and then homoisocitrate. This is then decarboxylated to form alpha-ketoadipate, which is then converted to alpha-aminoadipate. This is then reduced to form alpha-aminoadipate 6-semialdehyde, which is metabolized to saccharopine and finally L-lysine.
Also Known As "lysine biosynthesis via aminoadipic acid and saccharopine" ; "lysine biosynthetic process via aminoadipic acid and saccharopine"
Comment
Links to External Ontologies
  QuickGO data     AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS
No relevant records available
Records annotated with this exact term (annotations to child terms are NOT included)
No relevant records available
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
No relevant statements available
Spanning Tree (Parents/Children)
Only view relationship: 
  lysine biosynthetic process
   |__lysine biosynthetic process via aminoadipic acid
       |__lysine biosynthetic process via alpha-aminoadipate and saccharopine
           |__regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine
               |__negative regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine
               |__positive regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine
Spanning Tree View Settings
Parents/Children
View Depth
Show hierarchy levels: for parents, for children
hide Relationships
Is a lysine biosynthetic process via aminoadipic acid
Part of
hide Synonyms & Secondary IDs
Synonyms
  • "lysine biosynthesis via aminoadipic acid and saccharopine" EXACT
    "lysine biosynthetic process via aminoadipic acid and saccharopine" EXACT
Secondary IDs
hide External Crossreferences & Linkouts
MetaCyc:LYSINE-AMINOAD-PWY