FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term symbiont-mediated suppression of host innate immune response ID (Ontology) GO:0052170 (Gene Ontology)
Definition A process in which a symbiont inhibits or disrupts the normal execution of the innate immune response of the host organism, the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Also Known As "down regulation by symbiont of host innate immunity" ; "down-regulation by symbiont of host innate immunity" ; "downregulation by symbiont of host innate immunity" (for all, see Synonyms field below)
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symbiont-mediated perturbation of host immune response
 |__symbiont-mediated perturbation of host innate immune response__
 |__symbiont-mediated suppression of host immune response__________|
                                                                   symbiont-mediated suppression of host innate immune response
                                                                    |__effector-mediated suppression of host innate immune response
                                                                    |   |__effector-mediated activation of host programmed cell death by symbiont(+)
                                                                    |   |__effector-mediated suppression of host pattern-triggered immunity(+)
                                                                    |__symbiont-mediated suppression of host complement activation
                                                                    |   |__symbiont-mediated suppression of host complement activation by activation of host proteases
                                                                    |   |__symbiont-mediated suppression of host complement activation by complement sequestering
                                                                    |   |__symbiont-mediated suppression of host complement activation by inactivation of complement proteins
                                                                    |   |__symbiont-mediated suppression of host complement activation by recruitment of complement control protein
                                                                    |__symbiont-mediated suppression of host ISG15-protein conjugation
                                                                    |__symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host IRF9 activity
                                                                    |__symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host TYK2 activity
                                                                    |__symbiont-mediated suppression of host pathogen-associated molecular pattern receptor signaling pathway
                                                                    |   |__symbiont-mediated suppression of cytoplasmic pattern recognition receptor signaling pathway(+)
                                                                    |__symbiont-mediated suppression of host RNAi-mediated antiviral immune response
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Is a symbiont-mediated perturbation of host innate immune response
symbiont-mediated suppression of host immune response
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Synonyms
  • "down regulation by symbiont of host innate immunity" EXACT
    "down-regulation by symbiont of host innate immunity" EXACT
    "downregulation by symbiont of host innate immunity" EXACT
    "inhibition by symbiont of host innate immunity" NARROW
    "negative regulation by symbiont of host innate immune response" EXACT
    "negative regulation by symbiont of host innate immunity" EXACT
    "negative regulation of host innate immune response" EXACT
    "negative regulation of innate immune response in other organism" BROAD
    "suppression by symbiont of host innate immune response" EXACT
    "suppression of host innate immune response" EXACT
Secondary IDs
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Reactome:R-HSA-9637687 "Suppression of phagosomal maturation"