FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term ergothioneine biosynthetic process ID (Ontology) GO:0052699 (Gene Ontology)
Definition The chemical reactions and pathways resulting in the formation of ergothioneine, a naturally occurring metabolite of histidine with antioxidant properties.
Also Known As "(2S)-3-(2-mercapto-1H-imidazol-5-yl)-2-(trimethylazaniumyl)propanoate biosynthetic process" ; "2-mercaptoergothioneine trimethylbetaine anabolism" ; "2-mercaptoergothioneine trimethylbetaine biosynthesis" (for all, see Synonyms field below)
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Spanning Tree (Parents/Children)
Only view relationship: 
sulfur amino acid metabolic process
 |__sulfur amino acid biosynthetic process___
 |__ergothioneine metabolic process__________|
amino-acid betaine metabolic process         |
 |__amino-acid betaine biosynthetic process__|
 |__ergothioneine metabolic process__________|
modified amino acid biosynthetic process     |
 |__amino-acid betaine biosynthetic process__|
 |__modified histidine biosynthetic process__|
sulfur compound biosynthetic process         |
 |__sulfur amino acid biosynthetic process___|
carboxylic acid biosynthetic process         |
 |__sulfur amino acid biosynthetic process___|
                                             ergothioneine biosynthetic process
                                              |__ergothioneine biosynthesis from histidine via gamma-glutamyl-hercynylcysteine sulfoxide
                                              |__ergothioneine biosynthesis from histidine via hercynylcysteine sulfoxide synthase
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Is a sulfur amino acid biosynthetic process
amino-acid betaine biosynthetic process
ergothioneine metabolic process
modified histidine biosynthetic process
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Synonyms
  • "(2S)-3-(2-mercapto-1H-imidazol-5-yl)-2-(trimethylazaniumyl)propanoate biosynthetic process" EXACT
    "2-mercaptoergothioneine trimethylbetaine anabolism" EXACT
    "2-mercaptoergothioneine trimethylbetaine biosynthesis" EXACT
    "2-mercaptoergothioneine trimethylbetaine biosynthetic process" EXACT
    "2-mercaptoergothioneine trimethylbetaine formation" EXACT
    "2-mercaptoergothioneine trimethylbetaine synthesis" EXACT
    "ergothioneine anabolism" EXACT
    "ergothioneine biosynthesis" EXACT
    "ergothioneine formation" EXACT
    "ergothioneine synthesis" EXACT
Secondary IDs
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