FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term canonical Wnt signaling pathway ID (Ontology) GO:0060070 (Gene Ontology)
Definition A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.[ PubMed:11532397 PubMed:19619488 ]
Also Known As "canonical Wnt receptor signaling pathway" ; "canonical Wnt-activated signaling pathway" ; "Wnt receptor signaling pathway through beta-catenin" (for all, see Synonyms field below)
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Annotations
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Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS      19
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Relevant FlyBase reports
 Gene Groups Genes
 canonical Wnt signaling pathway (all annotations which use CV term, excluding "NOT" statements)       2     19
     involved_in | canonical Wnt signaling pathway       --      19
Spanning Tree (Parents/Children)
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  cell surface receptor signaling pathway
   |__Wnt signaling pathway
       |__canonical Wnt signaling pathway  131 rec.
           |__beta-catenin destruction complex disassembly
           |__canonical Wnt signaling pathway involved in heart development
           |__canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation
           |__canonical Wnt signaling pathway involved in negative regulation of apoptotic process
           |__canonical Wnt signaling pathway involved in positive regulation of apoptotic process
           |__regulation of canonical Wnt signaling pathway 110 rec.
               |__negative regulation of canonical Wnt signaling pathway 51 rec.
               |__positive regulation of canonical Wnt signaling pathway 60 rec.
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Is a Wnt signaling pathway
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Synonyms
  • "canonical Wnt receptor signaling pathway" EXACT
    "canonical Wnt-activated signaling pathway" EXACT
    "frizzled-1 receptor signaling pathway" NARROW
    "Wnt receptor signaling pathway through beta-catenin" EXACT
    "Wnt receptor signaling pathway via beta-catenin" EXACT
    "Wnt receptor signalling pathway through beta-catenin" EXACT
Secondary IDs
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Reactome:R-HSA-4641262 "Disassembly of the destruction complex and recruitment of AXIN to the membrane"