FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term cardiac epithelial to mesenchymal transition ID (Ontology) GO:0060317 (Gene Ontology)
Definition A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.[ PubMed:16314491 PubMed:1996351 ]
Also Known As "heart epithelial to mesenchymal transition"
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Spanning Tree (Parents/Children)
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heart development
 |__heart morphogenesis___________________
animal organ morphogenesis                |
 |__heart morphogenesis___________________|
mesenchymal cell differentiation          |
 |__epithelial to mesenchymal transition__|
                                          cardiac epithelial to mesenchymal transition
                                           |__endocardial cushion to mesenchymal transition
                                           |   |__endocardial cushion to mesenchymal transition involved in cardiac skeleton development
                                           |   |__endocardial cushion to mesenchymal transition involved in heart chamber septation
                                           |   |__endocardial cushion to mesenchymal transition involved in heart valve formation(+)
                                           |   |__regulation of endocardial cushion to mesenchymal transition(+)
                                           |__epithelial to mesenchymal transition involved in cardiac fibroblast development
                                           |__epithelial to mesenchymal transition involved in coronary vasculature morphogenesis
                                           |__epithelial to mesenchymal transition involved in endocardial cushion formation
                                           |   |__regulation of epithelial to mesenchymal transition involved in endocardial cushion formation(+)
                                           |__regulation of cardiac epithelial to mesenchymal transition
                                               |__negative regulation of cardiac epithelial to mesenchymal transition(+)
                                               |__positive regulation of cardiac epithelial to mesenchymal transition(+)
                                               |__regulation of endocardial cushion to mesenchymal transition(+)
                                               |__regulation of epithelial to mesenchymal transition involved in endocardial cushion formation(+)
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Is a epithelial to mesenchymal transition
Part of heart morphogenesis
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Synonyms
  • "heart epithelial to mesenchymal transition" EXACT
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