FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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Term chaperone-mediated autophagy ID (Ontology) GO:0061684 (Gene Ontology)
Definition The autophagy process which begins when chaperones and co-chaperones recognize a target motif and unfold the substrate protein. The proteins are then transported to the lysosome where they are degraded.[ PubMed:22743996 PubMed:23434281 ]
Also Known As "chaperone-assisted selective autophagy"
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catabolic process
 |__autophagy___________________________
macromolecule catabolic process         |
 |__protein catabolic process___________|
protein metabolic process               |
 |__protein catabolic process___________|
process utilizing autophagic mechanism  |
 |__autophagy___________________________|
                                        chaperone-mediated autophagy
                                         |__chaperone-mediated autophagy translocation complex assembly
                                         |__protein targeting to lysosome involved in chaperone-mediated autophagy
                                         |__regulation of chaperone-mediated autophagy
                                             |__negative regulation of chaperone-mediated autophagy
                                             |__positive regulation of chaperone-mediated autophagy
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protein catabolic process
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Reactome:R-HSA-9613829 "Chaperone Mediated Autophagy"
Wikipedia:Chaperone-mediated_autophagy