FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term type 2 mitophagy ID (Ontology) GO:0061734 (Gene Ontology)
Definition The selective autophagy process in which a mitochondrion is degraded by macroautophagy in a process initiated by mitochondrial depolarization (mtDepo) followed by Parkin binding, and ubiquitination of outer membrane proteins, to remove potentially harm-inducing dysfunctional/damaged mitochondria.[ PubMed:25009776 PubMed:25349190 ]
Also Known As "Park2-mediated mitophagy in response to mitochondrial depolarization" ; "parkin-mediated mitophagy in response to mitochondrial depolarization" ; "PRKN-mediated mitophagy in response to mitochondrial depolarization"
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Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS       2
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Relevant FlyBase reports
 Genes
 type 2 mitophagy (all annotations which use CV term, excluding "NOT" statements)       2
     involved_in | type 2 mitophagy       2
Spanning Tree (Parents/Children)
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autophagy of mitochondrion__
macroautophagy______________|
                            mitophagy
                             |__type 2 mitophagy  4 rec.
                                 |__regulation of type 2 mitophagy 2 rec.
                                     |__negative regulation of type 2 mitophagy 1 rec.
                                     |__positive regulation of type 2 mitophagy 1 rec.
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Synonyms
  • "Park2-mediated mitophagy in response to mitochondrial depolarization" EXACT
    "parkin-mediated mitophagy in response to mitochondrial depolarization" EXACT
    "PRKN-mediated mitophagy in response to mitochondrial depolarization" EXACT
Secondary IDs
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