FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress ID (Ontology) GO:0070059 (Gene Ontology)
Definition The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.[ PubMed:18701708 ]
Also Known As "apoptosis in response to ER stress" ; "apoptosis triggered by ER stress" ; "endoplasmic reticulum stress-induced apoptosis" (for all, see Synonyms field below)
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Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS       5
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Relevant FlyBase reports
 Genes
 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (all annotations which use CV term, excluding "NOT" statements)       5
     involved_in | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress       5
Spanning Tree (Parents/Children)
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cellular response to stress
 |__response to endoplasmic reticulum stress__
intracellular signal transduction             |
 |__intrinsic apoptotic signaling pathway_____|
apoptotic signaling pathway                   |
 |__intrinsic apoptotic signaling pathway_____|
                                              intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  7 rec.
                                               |__neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
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Is a response to endoplasmic reticulum stress
intrinsic apoptotic signaling pathway
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Synonyms
  • "apoptosis in response to endoplasmic reticulum stress" BROAD
    "apoptosis in response to ER stress" EXACT
    "apoptosis triggered by ER stress" EXACT
    "endoplasmic reticulum stress-induced apoptosis" EXACT
    "ER stress-induced apoptosis" EXACT
    "intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress" EXACT
Secondary IDs
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