Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
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| Term | cornification | ID (Ontology) | GO:0070268 (Gene Ontology) |
| Definition | A type of programmed cell death that occurs in the epidermis, morphologically and biochemically distinct from apoptosis. It leads to the formation of corneocytes, i.e. dead keratinocytes containing an amalgam of specific proteins (e.g., keratin, loricrin, SPR and involucrin) and lipids (e.g., fatty acids and ceramides), which are necessary for the function of the cornified skin layer (mechanical resistance, elasticity, water repellence and structural stability).[ PubMed:18846107 ] | ||
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cell death |__programmed cell death |__cornification |
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| Is a | programmed cell death | ||
| Part of | keratinization | ||
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| Reactome:R-HSA-6809371 "Formation of the cornified envelope" | |||
