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General Information
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| Term |
ERK1 and ERK2 cascade |
ID (Ontology) |
GO:0070371 (Gene Ontology) |
| Definition |
A MAPK cascade containing at least the ERK1 or ERK2 MAP kinases. It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and of ERK1 or ERK2. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier. The ERK1/ERK2 cascade is activated by mitogens, growth factors, G protein-coupled receptors, and results in cellular responses such as cell proliferation, cell differentiation and development.[ PubMed:20811974 PubMed:23125017 PubMed:28903453 ] |
| Also Known As |
"ERK1 and ERK2 signaling pathway" ; "ERK1 and ERK2 signalling pathway" ; "ERK1/2 cascade" (for all, see Synonyms field below) |
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Links to External Ontologies
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QuickGO data AmiGO data
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Annotations
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Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
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| Data Class | Field | Records |
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| Genes (FBgn) | GO_BIOLOGICAL_PROCESS | 3 |
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Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
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| Full annotation statements | Relevant FlyBase reports |
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| Genes |
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ERK1 and ERK2 cascade (all annotations which use CV term, excluding "NOT" statements) | 3 | involved_in | ERK1 and ERK2 cascade | 3 |
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Relationships
