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General Information
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| Term |
ERK5 cascade |
ID (Ontology) |
GO:0070375 (Gene Ontology) |
| Definition |
A MAPK cascade containing at least the ERK5 MAP kinase (MAPK7; also called BMK1). It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and of ERK5. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. The ERK5 cascade is activated by stress, mitogens, and by G protein-coupled receptors, and results in cellular responses such as cell growth, cell differentiation and development.[ PubMed:16376520 PubMed:16880823 PubMed:20811974 PubMed:23125017 PubMed:28903453 ] |
| Also Known As |
"big MAP kinase signaling cascade" ; "BMK cascade" ; "BMK signaling pathway" (for all, see Synonyms field below) |
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Links to External Ontologies
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QuickGO data AmiGO data
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Annotations
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Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
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No relevant records available
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Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
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No relevant statements available
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Relationships
