FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
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Term siRNA-mediated gene silencing by inhibition of translation ID (Ontology) GO:0070549 (Gene Ontology)
Definition An siRNA-mediated post-transcriptional gene silencing pathway that blocks the translation of target mRNAs into proteins. Once incorporated into a RNA-induced silencing complex (RISC), an siRNA will typically mediate repression of translation if the siRNA perfectly complements elements located in the 3' untranslated region of target mRNAs.[ PubMed:18771919 ]
Also Known As "RNA interference, negative regulation of translation"
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regulation of translation
 |__negative regulation of translation_________________________
negative regulation of gene expression                         |
 |__negative regulation of translation_________________________|
regulatory ncRNA-mediated post-transcriptional gene silencing  |
 |__siRNA-mediated post-transcriptional gene silencing_________|
negative regulation of protein metabolic process               |
 |__negative regulation of translation_________________________|
                                                               siRNA-mediated gene silencing by inhibition of translation
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Is a negative regulation of translation
siRNA-mediated post-transcriptional gene silencing
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Synonyms
  • "down regulation of translation involved in RNA interference" BROAD
    "down-regulation of translation involved in RNA interference" BROAD
    "downregulation of translation involved in RNA interference" BROAD
    "inhibition of translation involved in RNA interference" BROAD
    "negative regulation of translation involved in RNA interference" BROAD
    "RNA interference, negative regulation of translation" EXACT
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