FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term Shc-Grb2-Sos complex ID (Ontology) GO:0070619 (Gene Ontology)
Definition A protein complex that contains Grb2, the adaptor protein Shc and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway.[ PubMed:7970708 PubMed:8940013 ]
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plasma membrane___________
membrane protein complex__|
                          plasma membrane protein complex
                           |__Shc-Grb2-Sos complex
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Is a plasma membrane protein complex
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Synonyms
  • "Shc-Grb2-mSos1 complex, EGF stimulated" NARROW
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