FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term PAS complex ID (Ontology) GO:0070772 (Gene Ontology)
Definition A phosphatidylinositol kinase complex that contains a phosphatidylinositol-3-phosphate 5-kinase subunit (Fab1p in yeast; PIKFYVE in mammals), a kinase activator, and a phosphatase, and may also contain additional proteins; it is involved in regulating the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate. In mammals the complex is composed of PIKFYVE, FIG4 and VAC14. In yeast it is composed of Atg18p, Fig4p, Fab1p, Vac14p and Vac7p.[ PubMed:18950639 PubMed:19037259 PubMed:19158662 ]
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Annotations
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Data Class Field Records
Genes (FBgn)  GO_CELLULAR_COMPONENT       3
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 Genes
 PAS complex (all annotations which use CV term, excluding "NOT" statements)       3
     part_of | PAS complex       3
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vacuole
 |__vacuolar membrane_______________________________________________
membrane                                                            |
 |__membrane protein complex________________________________________|
protein-containing complex                                          |
 |__membrane protein complex________________________________________|
bounding membrane of organelle                                      |
 |__vacuolar membrane_______________________________________________|
transferase complex                                                 |
 |__transferase complex, transferring phosphorus-containing groups__|
                                                                    PAS complex  3 rec.
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Is a transferase complex, transferring phosphorus-containing groups
membrane protein complex
Part of vacuolar membrane
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Synonyms
  • "autophagy-specific phosphatidylinositol 3-kinase complex" RELATED[ PubMed:24165940 ]
Secondary IDs
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