FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term Sin3-type complex ID (Ontology) GO:0070822 (Gene Ontology)
Definition Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex.[ PubMed:15565322 PubMed:18292778 ]
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_CELLULAR_COMPONENT      12
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Relevant FlyBase reports
 Genes
 Sin3-type complex (all annotations which use CV term, excluding "NOT" statements)      12
     part_of | Sin3-type complex      12
Spanning Tree (Parents/Children)
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nucleoplasm
 |__histone deacetylase complex_____
chromosome                          |
 |__nuclear chromosome______________|
 |__chromatin_______________________|
nuclear lumen                       |
 |__nuclear chromosome______________|
cellular anatomical structure       |
 |__chromatin_______________________|
nuclear protein-containing complex  |
 |__histone deacetylase complex_____|
catalytic complex                   |
 |__histone deacetylase complex_____|
                                    Sin3-type complex  12 rec.
                                     |__Rpd3L complex
                                     |__Rpd3S complex
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Is a histone deacetylase complex
Part of nuclear chromosome
chromatin
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