FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term microprocessor complex ID (Ontology) GO:0070877 (Gene Ontology)
Definition A protein complex that binds to heme and to pri-miRNAs, and is required for the formation of a pre-microRNA (pre-miRNA), the initial step of microRNA (miRNA) biogenesis. The complex is composed of the double-stranded-RNA-specific RNase Drosha (also called RNASEN) and the RNA-binding protein DGCR8 (heme-free or heme-bound forms). Within the complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs RNASEN/Drosha to cleave the 3' and 5' strands of a stem-loop to release hairpin-shaped pre-miRNAs.[ PubMed:16963499 PubMed:17159994 ]
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Data Class Field Records
Genes (FBgn)  GO_CELLULAR_COMPONENT       2
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 microprocessor complex (all annotations which use CV term, excluding "NOT" statements)       2
     part_of | microprocessor complex       2
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nucleus
 |__nuclear protein-containing complex__
protein-containing complex              |
 |__nuclear protein-containing complex__|
endoribonuclease complex                |
 |__ribonuclease III complex____________|
                                        microprocessor complex  2 rec.
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Is a nuclear protein-containing complex
ribonuclease III complex
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