FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
Help Close All Open All
General Information
Term RISC complex assembly ID (Ontology) GO:0070922 (Gene Ontology)
Definition The process in which a single-stranded small RNA is incorporated within the RNA-initiated silencing complex (RISC). The assembly includes the maturation of the small RNA, the stabilization of the complex by accessory proteins of the RISC complex, duplex separation and the release of the second strand, forming a base-pairing complement complex that mediates gene silencing by small RNA.[ PubMed:14512631 PubMed:14744438 PubMed:19239886 PubMed:22233755 PubMed:27184117 ]
Comment
Links to External Ontologies
  QuickGO data     AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS
    Results list data from multiple species. Click on a button above and use the 'Filter by species' options on the resulting HitList to retrieve species-specific data.
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS      11
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 RISC complex assembly (all annotations which use CV term, excluding "NOT" statements)       4     11
     involved_in | RISC complex assembly       --      11
Spanning Tree (Parents/Children)
Only view relationship: 
negative regulation of gene expression
 |__regulatory ncRNA-mediated gene silencing__
ribonucleoprotein complex biogenesis          |
 |__protein-RNA complex assembly______________|
protein-containing complex assembly           |
 |__protein-RNA complex assembly______________|
protein-RNA complex organization              |
 |__protein-RNA complex assembly______________|
                                              RISC complex assembly  15 rec.
Spanning Tree View Settings
Parents/Children
View Depth
Show hierarchy levels: for parents, for children
hide Relationships
Is a protein-RNA complex assembly
Part of regulatory ncRNA-mediated gene silencing
hide Synonyms & Secondary IDs
Synonyms
  • "gene silencing by RNA, small RNA loading onto RISC" RELATED
    "miRISC assembly" BROAD
    "miRNA loading onto RISC" NARROW
    "RISC assembly" RELATED
    "siRNA loading onto RISC involved in gene silencing by small RNA" NARROW
    "siRNA loading onto RISC involved in RNA interference" NARROW
    "small RNA loading onto RISC" RELATED
Secondary IDs
hide External Crossreferences & Linkouts