FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term error-free translesion synthesis ID (Ontology) GO:0070987 (Gene Ontology)
Definition The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions but does not causes an increase in the endogenous mutation level. For S. cerevisiae, RAD30 encodes DNA polymerase eta, which incorporates two adenines. When incorporated across a thymine-thymine dimer, it does not increase the endogenous mutation level.
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Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS       2
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 Genes
 error-free translesion synthesis (all annotations which use CV term, excluding "NOT" statements)       2
     involved_in | error-free translesion synthesis       2
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DNA damage tolerance_______________________
DNA synthesis involved in DNA replication__|
                                           translesion synthesis
                                            |__error-free translesion synthesis  2 rec.
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Reactome:R-HSA-110320 "Translesion Synthesis by POLH"