FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term heteromeric SMAD protein complex ID (Ontology) GO:0071144 (Gene Ontology)
Definition A protein complex composed of SMAD family proteins, a transcription factor complex which binds to the promoters of target genes and recruits co-activators and histone acetyltransferases, facilitating transcription. Phosphorylation of the non-SMAD4 subunit(s) enables binding of SMAD4 to form heteromeric complexes that enter the nucleus to initiate gene transcription. DNA-binding specificity is conferred by other transcription factors binding to SMAD complexes. Interactions with coactivators or corepressors modulate their transcriptional activity. Can be heterotrimeric or heterodimeric.[ PubMed:11779505 PubMed:15350224 PubMed:16322555 PubMed:9389648 PubMed:9670020 ]
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Data Class Field Records
Genes (FBgn)  GO_CELLULAR_COMPONENT       4
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 Genes
 heteromeric SMAD protein complex (all annotations which use CV term, excluding "NOT" statements)       4
     part_of | heteromeric SMAD protein complex       4
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transcription regulator complex
 |__RNA polymerase II transcription regulator complex__
protein-containing complex                             |
 |__SMAD protein complex_______________________________|
nuclear protein-containing complex                     |
 |__RNA polymerase II transcription regulator complex__|
                                                       heteromeric SMAD protein complex  4 rec.
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Is a SMAD protein complex
RNA polymerase II transcription regulator complex
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Synonyms
  • "SMAD1-SMAD4 protein complex" NARROW
    "SMAD2-SMAD3-SMAD4 protein complex" NARROW
    "SMAD2-SMAD4 protein complex" NARROW
    "SMAD3-SMAD4 protein complex" NARROW
Secondary IDs
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