FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term death-inducing signaling complex assembly ID (Ontology) GO:0071550 (Gene Ontology)
Definition A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by a death domain (DD) interaction, as part of the extrinsic apoptotic signaling pathway.
Also Known As "DD-mediated complex assembly" ; "death domain-mediated complex assembly" ; "death domain-mediated complex assembly involved in extrinsic apoptotic pathway" (for all, see Synonyms field below)
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Spanning Tree (Parents/Children)
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cell surface receptor signaling pathway
 |__extrinsic apoptotic signaling pathway__
cellular component assembly                |
 |__protein-containing complex assembly____|
protein-containing complex organization    |
 |__protein-containing complex assembly____|
apoptotic signaling pathway                |
 |__extrinsic apoptotic signaling pathway__|
                                           death-inducing signaling complex assembly
                                            |__regulation of death-inducing signaling complex assembly
                                            |   |__negative regulation of death-inducing signaling complex assembly
                                            |__TRAIL death-inducing signaling complex assembly
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Is a protein-containing complex assembly
Part of extrinsic apoptotic signaling pathway
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Synonyms
  • "DD-mediated complex assembly" EXACT
    "death domain-mediated complex assembly" EXACT
    "death domain-mediated complex assembly involved in extrinsic apoptotic pathway" EXACT
    "death-inducing signaling complex formation" EXACT
    "death-inducing signalling complex assembly" EXACT
    "DISC assembly" EXACT
    "DISC formation" EXACT
Secondary IDs
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Reactome:R-HSA-5357786 "TNFR1-induced proapoptotic signaling"