FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term ubiquitin-dependent protein catabolic process via the N-end rule pathway ID (Ontology) GO:0071596 (Gene Ontology)
Definition The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the N-end rule pathway. In the N-end rule pathway, destabilizing N-terminal residues (N-degrons) in substrates are recognized by E3 ligases (N-recognins), whereupon the substrates are linked to ubiquitin and then delivered to the proteasome for degradation.[ PubMed:19246002 PubMed:9112437 ]
Also Known As "ubiquitin-dependent protein breakdown via the N-end rule pathway" ; "ubiquitin-dependent protein catabolism via the N-end rule pathway" ; "ubiquitin-dependent protein degradation via the N-end rule pathway"
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Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS       5
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Relevant FlyBase reports
 Genes
 ubiquitin-dependent protein catabolic process via the N-end rule pathway (all annotations which use CV term, excluding "NOT" statements)       5
     involved_in | ubiquitin-dependent protein catabolic process via the N-end rule pathway       5
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ubiquitin-dependent protein catabolic process__
proteasomal protein catabolic process__________|
                                               proteasome-mediated ubiquitin-dependent protein catabolic process
                                                |__ubiquitin-dependent protein catabolic process via the N-end rule pathway  5 rec.
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Is a proteasome-mediated ubiquitin-dependent protein catabolic process
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Synonyms
  • "ubiquitin-dependent protein breakdown via the N-end rule pathway" EXACT
    "ubiquitin-dependent protein catabolism via the N-end rule pathway" EXACT
    "ubiquitin-dependent protein degradation via the N-end rule pathway" EXACT
Secondary IDs
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